1-(2-aminoethyl)-3,5-bis-(2-fluorobenzylidene)-4-piperidone

Base Information

• Chemical Name: 1-(2-aminoethyl)-3,5-bis-(2-fluorobenzylidene)-4-piperidone
• CAS No.: 1357390-42-1
• Molecular Formula: C₂₁H₂₀F₂N₂O
• Molecular Weight: 354.399
• Mol file: 1357390-42-1.mol

Synonyms:1-(2-aminoethyl)-3,5-bis-(2-fluorobenzylidene)-4-piperidone

Chemical Property of 1-(2-aminoethyl)-3,5-bis-(2-fluorobenzylidene)-4-piperidone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-aminoethyl)-3,5-bis-(2-fluorobenzylidene)-4-piperidone

There total 2 articles about 1-(2-aminoethyl)-3,5-bis-(2-fluorobenzylidene)-4-piperidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

3,5-bis-(2-fluorobenzylidene)-4-piperidone acetic acid (342808-41-7) + 2-bromoethylamine hydrobromide (2576-47-8) → 1-(2-aminoethyl)-3,5-bis-(2-fluorobenzylidene)-4-piperidone (1357390-42-1)

Guidance literature:

With caesium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 18h;

DOI:10.1111/j.1747-0285.2011.01271.x

Reference yield:

4-piperidone hydrochloride (41979-39-9) → 1-(2-aminoethyl)-3,5-bis-(2-fluorobenzylidene)-4-piperidone (1357390-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 48 h / 20 °C

2: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 18 h / 80 °C

With caesium carbonate; potassium iodide; In N,N-dimethyl-formamide;

DOI:10.1111/j.1747-0285.2011.01271.x

Reference yield: 62.0%

1-(2-aminoethyl)-3,5-bis-(2-fluorobenzylidene)-4-piperidone (1357390-42-1) + 2-(N'-tert-butoxycarbonylhydrazino)pyridine-5-carboxylic acid 2,5-dioxopyrrolidin-1-yl ester (133081-26-2) → N'-(5-{2-[3,5-bis-(2-fluorobenzylidene)-4-oxopiperidin-1-yl]ethylcarbamoyl}pyridin-2-yl)hydrazinecarboxylic acid tert-butyl ester (1357390-43-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1111/j.1747-0285.2011.01271.x

upstream raw materials:

3,5-bis-(2-fluorobenzylidene)-4-piperidone acetic acid

2-bromoethylamine hydrobromide

4-piperidone hydrochloride

Downstream raw materials:

N'-(5-{2-[3,5-bis-(2-fluorobenzylidene)-4-oxopiperidin-1-yl]ethylcarbamoyl}pyridin-2-yl)hydrazinecarboxylic acid tert-butyl ester

N-{2-[3,5-bis-(2-fluorobenzylidene)-4-oxo-piperidin-1-yl]-ethyl}-6-hydrazinonicotinamide