2-methoxy-17-(1-(4-(trifluoromethoxyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol

Base Information

Chemical Name:2-methoxy-17-(1-(4-(trifluoromethoxyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol
CAS No.:1620910-41-9
Molecular Formula:C₂₈H₃₀F₃N₃O₄
Molecular Weight:529.559
Hs Code.:

Synonyms:2-methoxy-17-(1-(4-(trifluoromethoxyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-methoxy-17-(1-(4-(trifluoromethoxyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol

Chemical Property:

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Technology Process of 2-methoxy-17-(1-(4-(trifluoromethoxyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol

There total 5 articles about 2-methoxy-17-(1-(4-(trifluoromethoxyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1620910-10-2
3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-(4-(trifluoromethoxyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol

: 1620910-41-9
2-methoxy-17-(1-(4-(trifluoromethoxyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.steroids.2014.05.020

Reference yield:

: 362-08-3,7683-30-9
2-methoxyestrone

: 1620910-41-9
2-methoxy-17-(1-(4-(trifluoromethoxyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

2: tetrahydrofuran / 4.75 h / 0 - 20 °C

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 50 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

With 1H-imidazole; copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; sodium L-ascorbate; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.steroids.2014.05.020

Reference yield:

: 767352-05-6
3-O-(tert-butyl)dimethylsilyl-2-methoxyestrone

: 1620910-41-9
2-methoxy-17-(1-(4-(trifluoromethoxyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 4.75 h / 0 - 20 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 50 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

With copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; sodium L-ascorbate; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1016/j.steroids.2014.05.020