3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-(4-(trifluoromethoxyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol

Base Information

Chemical Name:3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-(4-(trifluoromethoxyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol
CAS No.:1620910-10-2
Molecular Formula:C₃₄H₄₄F₃N₃O₄Si
Molecular Weight:643.822
Hs Code.:

Synonyms:3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-(4-(trifluoromethoxyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol

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Chemical Property of 3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-(4-(trifluoromethoxyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol

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Technology Process of 3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-(4-(trifluoromethoxyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol

There total 4 articles about 3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-(4-(trifluoromethoxyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 876012-82-7
1‐azido‐4‐(trifluoromethoxy)benzene

: 1620910-47-5
3-O-(tert-butyl)dimethylsilyl-2-methoxyethynylestradiol

: 1620910-10-2
3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-(4-(trifluoromethoxyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 50 ℃; for 24h;
DOI:10.1016/j.steroids.2014.05.020

Reference yield:

: 362-08-3,7683-30-9
2-methoxyestrone

: 1620910-10-2
3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-(4-(trifluoromethoxyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

2: tetrahydrofuran / 4.75 h / 0 - 20 °C

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 50 °C

With 1H-imidazole; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.steroids.2014.05.020

Reference yield:

: 767352-05-6
3-O-(tert-butyl)dimethylsilyl-2-methoxyestrone

: 1620910-10-2
3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-(4-(trifluoromethoxyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 4.75 h / 0 - 20 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 50 °C

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1016/j.steroids.2014.05.020