N-(3-aminophenyl)-2-piperidin-1-ylacetamide

Base Information

• Chemical Name: N-(3-aminophenyl)-2-piperidin-1-ylacetamide
• CAS No.: 500119-40-4
• Molecular Formula: C₁₃H₁₉N₃O
• Molecular Weight: 233.313
• Mol file: 500119-40-4.mol

Synonyms:N-(3-aminophenyl)-2-(piperidin-1-yl)acetamide

Chemical Property of N-(3-aminophenyl)-2-piperidin-1-ylacetamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

N-(3-Aminophenyl)-2-(piperidin-1-yl)acetamide 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

Useful:

Technology Process of N-(3-aminophenyl)-2-piperidin-1-ylacetamide

There total 5 articles about N-(3-aminophenyl)-2-piperidin-1-ylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(3-nitrophenyl)-2-(piperidin-1-yl)acetamide (35763-43-0) → N-(3-aminophenyl)-2-(piperidin-1-yl)acetamide (500119-40-4)

Guidance literature:

With 10% palladium on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃;

DOI:10.1039/c0cc02917c

Reference yield:

piperidine (110-89-4) → N-(3-aminophenyl)-2-(piperidin-1-yl)acetamide (500119-40-4)

Guidance literature:

Multi-step reaction with 2 steps

2: acetic acid; zinc-powder; water

With water; acetic acid; zinc;

Reference yield:

3-nitro-aniline (99-09-2) → N-(3-aminophenyl)-2-(piperidin-1-yl)acetamide (500119-40-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 2.3 h / 20 °C / Cooling with ice

1.2: 14 h / 20 °C / Cooling with ice

2.1: 10% palladium on activated carbon; hydrogen / tetrahydrofuran / 20 °C

With 10% palladium on activated carbon; hydrogen; triethylamine; In tetrahydrofuran;

DOI:10.1039/c0cc02917c

upstream raw materials:

N-(3-nitrophenyl)-2-(piperidin-1-yl)acetamide

piperidine

2-chloro-N-(3-nitrophenyl)acetamide

3-nitro-aniline

Downstream raw materials:

N-(3-azidophenyl)-2-(piperidin-1-yl)acetamide

C₄₀H₄₂N₁₀O₂

Refernces

• 1、 Lombardo, Caterina Maria,Martinez, Iria Sanchez,Haider, Shozeb,Gabelica, Valerie,De Pauw, Edwin,Moses, John E.,Neidle, Stephen. "Structure-based design of selective high-affinity telomeric quadruplex-binding ligands". supporting information; experimental part. p. 9116 - 9118. Retrieved 2011/02/23.
• 2、 -. "THIAZOLIDINONES FOR USE AS INHIBITORS OF POLO-LIKE KINASE (PLK)". Page/Page column 46. . Retrieved 2008/06/13.