35763-43-0Relevant articles and documents
A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines
Lombardo, Caterina M.,Welsh, Sarah J.,Strauss, Sandra J.,Dale, Aaron G.,Todd, Alan K.,Nanjunda, Rupesh,Wilson, W. David,Neidle, Stephen
supporting information, p. 5984 - 5988 (2012/11/07)
A series of naphthalene derivatives with disubstituted triazole side-arms have been assembled by click chemistry. Lead compounds show a high level of selectivity for renal, osteo- and Ewing's sarcomas that express the HIF-1α transcription factor. They also interact selectively with the quadruplex DNAs located in the promoter of the HIF genes and it is suggested that the mechanism of action involves inhibition of transcription by drug-mediated quadruplex stabilization in these regions.
Metasubstituted thiazolidinones, their manufacture and use as a drug
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Page/Page column 37, (2010/11/25)
This invention involves thiazolidinone of general formula (I) and its creation and use as inhibitors of polo like kinase (PLK) for the treatment of various diseases.