Ethyl [1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro pyrazole-5-carboxylate

Base Information

• Chemical Name: Ethyl [1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro pyrazole-5-carboxylate
• CAS No.: 280120-68-5
• Molecular Formula: C₁₄H₁₁FN₄O₄
• Molecular Weight: 318.264

Synonyms:Ethyl [1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro pyrazole-5-carboxylate

Chemical Property of Ethyl [1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro pyrazole-5-carboxylate

Chemical Property:

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Technology Process of Ethyl [1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro pyrazole-5-carboxylate

There total 2 articles about Ethyl [1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro pyrazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Ethyl [1-(3-cyano-4-fluoro)phenyl]-3-methylpyrazole-5-carboxylate (209959-21-7) → Ethyl [1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro pyrazole-5-carboxylate (280120-68-5)

Guidance literature:

With ammonium nitrate; trifluoroacetic anhydride; In trifluoroacetic acid;

DOI:10.1016/j.bmcl.2006.07.002

Reference yield:

trifluoroacetic anhydride (407-25-0) + Ethyl [1-(3-cyano-4-fluoro)phenyl]-3-methylpyrazole-5-carboxylate (209959-21-7) → Ethyl [1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro pyrazole-5-carboxylate (280120-68-5)

Guidance literature:

With ammonium nitrate; In trifluoroacetic acid;

Reference yield: 80.0%

Ethyl [1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro pyrazole-5-carboxylate (280120-68-5) → [1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitropyrazole-5-carboxylic acid (280120-69-6)

Guidance literature:

With lithium hydroxide; In methanol;

DOI:10.1016/j.bmcl.2006.07.002

upstream raw materials:

Ethyl [1-(3-cyano-4-fluoro)phenyl]-3-methylpyrazole-5-carboxylate

trifluoroacetic anhydride

Downstream raw materials:

[1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitropyrazole-5-carboxylic acid

[1-(3-cyano-4-fluoro)phenyl]-3-methyl-6-(4-bromophenyl)-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one

[1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-amino-5-[(4-bromophenyl)aminocarbonyl]pyrazole

[1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro-5-[(4-bromophenyl)aminocarbonyl]pyrazole

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