[1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro-5-[(4-bromophenyl)aminocarbonyl]pyrazole

Base Information

Chemical Name:[1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro-5-[(4-bromophenyl)aminocarbonyl]pyrazole
CAS No.:280120-70-9
Molecular Formula:C₁₈H₁₁BrFN₅O₃
Molecular Weight:444.219
Hs Code.:

Synonyms:[1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro-5-[(4-bromophenyl)aminocarbonyl]pyrazole

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Chemical Property of [1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro-5-[(4-bromophenyl)aminocarbonyl]pyrazole

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Technology Process of [1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro-5-[(4-bromophenyl)aminocarbonyl]pyrazole

There total 5 articles about [1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro-5-[(4-bromophenyl)aminocarbonyl]pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 280120-69-6
[1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitropyrazole-5-carboxylic acid

: 79-37-8
oxalyl dichloride

: CH₂Cl₂/THF

: 106-40-1
4-bromo-aniline

: 280120-70-9
[1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro-5-[(4-bromophenyl)aminocarbonyl]pyrazole

Guidance literature:: With dmap; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 280120-69-6
[1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitropyrazole-5-carboxylic acid

: 280120-70-9
[1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro-5-[(4-bromophenyl)aminocarbonyl]pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: (COCl)2 / CH₂Cl₂

2: DMAP / CH₂Cl₂

With dmap; oxalyl dichloride; In dichloromethane;
DOI:10.1016/j.bmcl.2006.07.002

Reference yield:

: 280120-68-5
Ethyl [1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro pyrazole-5-carboxylate

: 280120-70-9
[1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro-5-[(4-bromophenyl)aminocarbonyl]pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / aq. LiOH / methanol

2: (COCl)2 / CH₂Cl₂

3: DMAP / CH₂Cl₂

With dmap; lithium hydroxide; oxalyl dichloride; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.07.002