4-(2-(2-amino-1-hydroxypropan-2-yl)-1H-benzo[d]imidazol-5-yl)-2-fluorobenzonitrile

Base Information

Chemical Name:4-(2-(2-amino-1-hydroxypropan-2-yl)-1H-benzo[d]imidazol-5-yl)-2-fluorobenzonitrile
CAS No.:1449474-44-5
Molecular Formula:C₁₇H₁₅FN₄O
Molecular Weight:310.331
Hs Code.:

Synonyms:4-(2-(2-amino-1-hydroxypropan-2-yl)-1H-benzo[d]imidazol-5-yl)-2-fluorobenzonitrile

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Chemical Property of 4-(2-(2-amino-1-hydroxypropan-2-yl)-1H-benzo[d]imidazol-5-yl)-2-fluorobenzonitrile

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Technology Process of 4-(2-(2-amino-1-hydroxypropan-2-yl)-1H-benzo[d]imidazol-5-yl)-2-fluorobenzonitrile

There total 5 articles about 4-(2-(2-amino-1-hydroxypropan-2-yl)-1H-benzo[d]imidazol-5-yl)-2-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1449475-79-9
tert-butyl (2-(5-(4-cyano-3-fluorophenyl)-1H-benzo[d]imidazol-2-yl)-1-hydroxypropan-2-yl)carbamate

: 1449474-44-5
4-(2-(2-amino-1-hydroxypropan-2-yl)-1H-benzo[d]imidazol-5-yl)-2-fluorobenzonitrile

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.5h;

Reference yield:

: 843663-18-3
(4-cyano-3-fluorophenyl)boronic acid

: 1449474-44-5
4-(2-(2-amino-1-hydroxypropan-2-yl)-1H-benzo[d]imidazol-5-yl)-2-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / tetrahydrofuran; water / 0.17 h / Inert atmosphere

1.2: 6 h / 65 °C

2.1: iron; ammonium chloride / water; ethanol / 1 h / Reflux

3.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; N,N-dimethyl-formamide / 18 h / 20 °C

3.2: 2 h / 65 °C

4.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With hydrogenchloride; iron; sodium carbonate; ammonium chloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1449475-98-2
3',4'-diamino-3-fluoro-[1,1'-biphenyl]-4-carbonitrile

: 1449474-44-5
4-(2-(2-amino-1-hydroxypropan-2-yl)-1H-benzo[d]imidazol-5-yl)-2-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; N,N-dimethyl-formamide / 18 h / 20 °C

1.2: 2 h / 65 °C

2.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With hydrogenchloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;