tert-butyl (2-(5-(4-cyano-3-fluorophenyl)-1H-benzo[d]imidazol-2-yl)-1-hydroxypropan-2-yl)carbamate

Base Information

Chemical Name:tert-butyl (2-(5-(4-cyano-3-fluorophenyl)-1H-benzo[d]imidazol-2-yl)-1-hydroxypropan-2-yl)carbamate
CAS No.:1449475-79-9
Molecular Formula:C₂₂H₂₃FN₄O₃
Molecular Weight:410.448
Hs Code.:

Synonyms:tert-butyl (2-(5-(4-cyano-3-fluorophenyl)-1H-benzo[d]imidazol-2-yl)-1-hydroxypropan-2-yl)carbamate

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Chemical Property of tert-butyl (2-(5-(4-cyano-3-fluorophenyl)-1H-benzo[d]imidazol-2-yl)-1-hydroxypropan-2-yl)carbamate

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Technology Process of tert-butyl (2-(5-(4-cyano-3-fluorophenyl)-1H-benzo[d]imidazol-2-yl)-1-hydroxypropan-2-yl)carbamate

There total 5 articles about tert-butyl (2-(5-(4-cyano-3-fluorophenyl)-1H-benzo[d]imidazol-2-yl)-1-hydroxypropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89500-39-0
2-((tert-butoxycarbonyl)amino)-3-hydroxy-2-methylpropanoic acid

: 1449475-98-2
3',4'-diamino-3-fluoro-[1,1'-biphenyl]-4-carbonitrile

: 1449475-79-9
tert-butyl (2-(5-(4-cyano-3-fluorophenyl)-1H-benzo[d]imidazol-2-yl)-1-hydroxypropan-2-yl)carbamate

Guidance literature:: 2-((tert-butoxycarbonyl)amino)-3-hydroxy-2-methylpropanoic acid; 3',4'-diamino-3-fluoro-[1,1'-biphenyl]-4-carbonitrile; With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In ethyl acetate; N,N-dimethyl-formamide; at 20 ℃; for 18h;

With acetic acid; at 65 ℃; for 2h;

Reference yield:

: 843663-18-3
(4-cyano-3-fluorophenyl)boronic acid

: 1449475-79-9
tert-butyl (2-(5-(4-cyano-3-fluorophenyl)-1H-benzo[d]imidazol-2-yl)-1-hydroxypropan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrahydrofuran; water / 0.17 h / Inert atmosphere

1.2: 6 h / 65 °C

2.1: iron; ammonium chloride / water; ethanol / 1 h / Reflux

3.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; N,N-dimethyl-formamide / 18 h / 20 °C

3.2: 2 h / 65 °C

With iron; sodium carbonate; ammonium chloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1449475-79-9
tert-butyl (2-(5-(4-cyano-3-fluorophenyl)-1H-benzo[d]imidazol-2-yl)-1-hydroxypropan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / water; methanol / 18 h / 0 - 20 °C

2.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; N,N-dimethyl-formamide / 18 h / 20 °C

2.2: 2 h / 65 °C

With sodium hydrogencarbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In methanol; water; ethyl acetate; N,N-dimethyl-formamide;