2-(((3Z,4R)-1-((S)-1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4-(2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-3-ylidene)acetic acid

Base Information

Chemical Name:2-(((3Z,4R)-1-((S)-1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4-(2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-3-ylidene)acetic acid
CAS No.:1430373-14-0
Molecular Formula:C₂₅H₂₆ClNO₆S
Molecular Weight:504.004
Hs Code.:

Synonyms:2-(((3Z,4R)-1-((S)-1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4-(2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-3-ylidene)acetic acid

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Chemical Property of 2-(((3Z,4R)-1-((S)-1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4-(2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-3-ylidene)acetic acid

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Technology Process of 2-(((3Z,4R)-1-((S)-1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4-(2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-3-ylidene)acetic acid

There total 16 articles about 2-(((3Z,4R)-1-((S)-1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4-(2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-3-ylidene)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 767612-34-0
R-130964

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 1430373-14-0,1287430-40-3
2-(((3Z,4R)-1-((S)-1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4-(2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-3-ylidene)acetic acid

Guidance literature:: In aq. phosphate buffer; acetonitrile; pH=7.4;

Reference yield: 52.0%

: 1610460-64-4
methyl (2S,3Z)-2-(2-chlorophenyl)-2-[3-(2-methoxy-2-oxoethylidene)-4-((2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-1-yl]acetate

: 1430373-14-0,1287430-40-3
2-(((3Z,4R)-1-((S)-1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4-(2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-3-ylidene)acetic acid

Guidance literature:: With hydrogenchloride; In water; at 40 - 45 ℃; for 36h;
DOI:10.1016/j.tet.2014.04.037

Reference yield:

: 85838-94-4
N-Boc-1,2,3,6-tetrahydropyridine

: 1430373-14-0,1287430-40-3
2-(((3Z,4R)-1-((S)-1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4-(2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-3-ylidene)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C

2.1: sodium hydroxide / water; acetonitrile / 24 h / 95 °C

3.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.75 h / -78 - -65 °C / Inert atmosphere

3.2: 1 h / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / -5 - 0 °C / Inert atmosphere

4.2: 2 h / 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

6.1: potassium hydrogencarbonate / acetonitrile / 72 h / 20 °C / Inert atmosphere

7.1: hydrogenchloride / water / 36 h / 40 - 45 °C

With hydrogenchloride; oxalyl dichloride; sodium hydride; potassium hydrogencarbonate; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile; mineral oil; 3.1: |Swern Oxidation / 4.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.tet.2014.04.037