(1R,cis)-3-<<2-amino-6-chloro-5-(4-chlorophenylazo)pyrimidin-4-yl>aminomethyl>-1,2,2-trimethylcyclopentylmethanol

Base Information

• Chemical Name: (1R,cis)-3-<<2-amino-6-chloro-5-(4-chlorophenylazo)pyrimidin-4-yl>aminomethyl>-1,2,2-trimethylcyclopentylmethanol
• CAS No.: 168974-89-8
• Molecular Formula: C₂₀H₂₆Cl₂N₆O
• Molecular Weight: 437.372
• Mol file: 168974-89-8.mol

Synonyms:(1R,cis)-3-<<2-amino-6-chloro-5-(4-chlorophenylazo)pyrimidin-4-yl>aminomethyl>-1,2,2-trimethylcyclopentylmethanol

Chemical Property of (1R,cis)-3-<<2-amino-6-chloro-5-(4-chlorophenylazo)pyrimidin-4-yl>aminomethyl>-1,2,2-trimethylcyclopentylmethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,cis)-3-<<2-amino-6-chloro-5-(4-chlorophenylazo)pyrimidin-4-yl>aminomethyl>-1,2,2-trimethylcyclopentylmethanol

There total 2 articles about (1R,cis)-3-<<2-amino-6-chloro-5-(4-chlorophenylazo)pyrimidin-4-yl>aminomethyl>-1,2,2-trimethylcyclopentylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

p-chlorobenzenediazonium chloride (2028-74-2) + (1R,cis)-3-<(2-amino-6-chloropyrimidin-4-yl)aminomethyl>-1,2,2-trimethylcyclopentylmethanol (168974-88-7) → (1R,cis)-3-<<2-amino-6-chloro-5-(4-chlorophenylazo)pyrimidin-4-yl>aminomethyl>-1,2,2-trimethylcyclopentylmethanol (168974-89-8)

Guidance literature:

DOI:10.1080/15257779508012365

Reference yield:

(1R,cis)-3-aminomethyl-1,2,2-trimethylcyclopentylmethanol (156767-18-9) → (1R,cis)-3-<<2-amino-6-chloro-5-(4-chlorophenylazo)pyrimidin-4-yl>aminomethyl>-1,2,2-trimethylcyclopentylmethanol (168974-89-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / triethylamine; butan-1-ol / 48 h / Heating

2: 83 percent / NaOAc / H₂O; acetic acid / Ambient temperature

With sodium acetate; In water; acetic acid; triethylamine; butan-1-ol;

DOI:10.1080/07328319708002530

Reference yield:

(1R,cis)-3-<<2-amino-6-chloro-5-(4-chlorophenylazo)pyrimidin-4-yl>aminomethyl>-1,2,2-trimethylcyclopentylmethanol (168974-89-8) → 5-Amino-3-((1S,3R)-3-hydroxymethyl-2,2,3-trimethyl-cyclopentylmethyl)-3,6-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / Zn / acetic acid; H₂O; ethanol / 6 h / Heating

2: 81 percent / NaNO₂ / H₂O; acetic acid / 0 deg C, 2 h; rt, 1 h

3: 94 percent / NaOH / H₂O / 6.5 h / Ambient temperature

With sodium hydroxide; zinc; sodium nitrite; In ethanol; water; acetic acid;

DOI:10.1080/07328319708002530

upstream raw materials:

p-chlorobenzenediazonium chloride

(1R,cis)-3-<(2-amino-6-chloropyrimidin-4-yl)aminomethyl>-1,2,2-trimethylcyclopentylmethanol

(1R,cis)-3-aminomethyl-1,2,2-trimethylcyclopentylmethanol