4-chlorobenzenediazonium Chloride

Base Information

• Chemical Name: 4-chlorobenzenediazonium Chloride
• CAS No.: 2028-74-2
• Molecular Formula: C6H4ClN2.Cl
• Molecular Weight: 175.017
• DSSTox Substance ID: DTXSID00473710
• Mol file: 2028-74-2.mol

Synonyms:2028-74-2;4-chlorobenzenediazonium;chloride;p-chlorobenzenediazonium chloride;4-chlorobenzene-1-diazonium chloride;4-chlorobenzenediazonium Chloride;Benzenediazonium, 4-chloro-, chloride;SCHEMBL1578783;4-Chlorophenyldiazonium chloride;DTXSID00473710;HDSKJRZKLHXPNF-UHFFFAOYSA-M

Chemical Property of 4-chlorobenzenediazonium Chloride

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 173.9751535
• Heavy Atom Count: 10
• Complexity: 129

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1[N+]#N)Cl.[Cl-]

Technology Process of 4-chlorobenzenediazonium Chloride

There total 14 articles about 4-chlorobenzenediazonium Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C12H10ClN3O (25965-33-7) → p-chlorobenzenediazonium chloride (2028-74-2)

Guidance literature:

With oxalyl dichloride; In toluene; for 0.166667h; Ambient temperature;

DOI:10.1039/a605013a

Reference yield: 88.0%

4-bromo-aniline (106-40-1) → (4-bromophenyl)diazonium chloride (2028-85-5) + p-chlorobenzenediazonium chloride (2028-74-2)

Guidance literature:

With hydrogenchloride; oxygen; nitrogen(II) oxide; In water; at 20 ℃; for 0.5h;

Reference yield: 69.0%

4-chloro-aniline (106-47-8) → (+-)-(1α,4α)-4-[[2-Amino-6-chloro-5-[4-chlorophenyl)azo]-4-pyrimidinyl]amino]-2-cyclopentene-1-methanol + p-chlorobenzenediazonium chloride (2028-74-2)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water;

upstream raw materials:

(Z)-(4-chloro-phenyl)-diazenecarbonitrile

N-(4-chloro-phenyl)-N'-sulfinyl-hydrazine

4-chloro-aniline

p-chloroaniline hydrochloride

Downstream raw materials:

1-azido-4-chlorobenzene

3-(4-chloro-phenyl)-1-phenyl-4,5-dihydro-1H-pyrazole

2-(4'-chlorophenylazo)-4-methylphenol

1,5-bis-(4-chloro-phenyl)-3-nitro-formazan

Refernces

Synthesis and antiviral activity of carbocyclic analogues of xylofuranosides of 2-amino-6-substituted-purines and 2-amino-6-substituted-8-azapurines

10.1021/jm00394a017

The research focused on the synthesis and antiviral activity of carbocyclic analogues of xylofuranosides of 2-amino-6-substituted-purines and 2-amino-6-substituted-8-azapurines. The purpose of this study was to explore the potential of these carbocyclic nucleoside analogues as antiviral agents, particularly against herpes simplex virus (HSV-1 and HSV-2), human cytomegalovirus (CMV), and varicella-zoster virus (VZV). The researchers synthesized a series of compounds, including carbocyclic xylofuranosylguanine (C-xylo-G, compound 9) and its 8-aza analogue (compound 13), through a series of chemical reactions involving precursors such as 2-amino-4,6-dichloropyrimidine and 2-azabicyclo[2.2.1]hept-5-en-3-one. The conclusions drawn from the study were that compounds 9 and 13 exhibited significant antiviral activity, with compound 9 being more potent against both HSV-1 and HSV-2. Additionally, compound 9 demonstrated potent activity against CMV and VZV, making it a promising candidate for further in vivo studies. The chemicals used in the synthesis process included various reagents and solvents such as triethyl orthoformate, acetic acid, zinc dust, p-chlorobenzenediazonium chloride, and dimethylformamide, among others.