2-(2-(benzylamino)ethylamino)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)ethanol

Base Information

Chemical Name:2-(2-(benzylamino)ethylamino)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)ethanol
CAS No.:1223578-31-1
Molecular Formula:C₂₂H₂₁F₆N₃O
Molecular Weight:457.419
Hs Code.:

Synonyms:2-(2-(benzylamino)ethylamino)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)ethanol

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Chemical Property of 2-(2-(benzylamino)ethylamino)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)ethanol

Chemical Property:

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Technology Process of 2-(2-(benzylamino)ethylamino)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)ethanol

There total 4 articles about 2-(2-(benzylamino)ethylamino)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 57120-54-4
4-(oxiran-2-yl)-2,8-bis(trifluoromethyl)quinoline

: 4152-09-4
N-benzylethylenediamine

: 1223578-31-1
2-(2-(benzylamino)ethylamino)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)ethanol

Guidance literature:: In ethanol; at 130 ℃; under 14221.9 Torr; Microwave irradiation;
DOI:10.1016/j.bmcl.2010.01.001

Reference yield:

: 35853-45-3
(2,8-bis-trifluoromethyl)-4-bromoquinoline

: 1223578-31-1
2-(2-(benzylamino)ethylamino)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine / toluene / 4 h / 20 °C / Inert atmosphere

1.2: 0.5 h / Inert atmosphere

2.1: potassium carbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / Reflux

3.1: ethanol / 0.25 h / Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; toluene;
DOI:10.1021/jm200647u

Reference yield:

: 1031928-53-6
2,8-bis(trifluoromethyl)-4-vinylquinoline

: 1223578-31-1
2-(2-(benzylamino)ethylamino)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / Reflux

2: ethanol / 0.25 h / Microwave irradiation

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane;
DOI:10.1021/jm200647u