4152-09-4

Basic information

• Product Name: N-Benzylethylenediamine
• Synonyms: N-Benzyl-1,2-ethanediamine ;N-Benzylethylenediamine SEE 16262, 97%;N-Benzylethylenediamine,99%;N-Benzylethylenediam;N-BenzylethylenediaMine, 97.0%(GC);N-Benzylethylenediamine 97%;1,2-Ethanediamine, N-(phenylmethyl)-;2-aminoethyl-(benzyl)amine
• CAS NO: 4152-09-4
• Molecular Formula: C₉H₁₄N₂
• Molecular Weight: 150.22
• EINECS: 223-984-5
• Product Categories: Polyamines;NULL;Benzene series
• Mol File: 4152-09-4.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 250°C
• Flash Point: 95°C
• Appearance: /
• Density: 1 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0129mmHg at 25°C
• Refractive Index: 1.5400
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 9.27±0.10(Predicted)
• Water Solubility: negligible
• BRN: 907505
• CAS DataBase Reference: N-Benzylethylenediamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzylethylenediamine(4152-09-4)
• EPA Substance Registry System: N-Benzylethylenediamine(4152-09-4)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 23-26-36/37/39-45
• RIDADR: 2735
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 4152-09-4(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

N-Benzylethylenediamine may be used for the synthesis of N-benzyl-N,N′,N′-tris(tert-butyloxycarbonylmethyl)ethylenediamine and 3-benzyl-2-(phenyl-2-sulfonate)-2-imidazoline tetraheptylammonium salt.

General Description

N-Benzylethylenediamine participates in the one-pot synthesis of N,N,N′-trisubstituted guanidines. It undergoes condensation with dibenzoylmethane (1,3-diphenyl-1,3-propanedione) in stoichiometric ratio 1:1 to afford the corresponding Schiff monobase.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C9H14N2/c10-6-7-11-8-9-4-2-1-3-5-9/h1-5,11H,6-8,10H2/p+2

Upstream product

• 104-71-2 N,N'-bis(benzyliden)ethylendiamine 
• 64-18-6 formic acid 
• 4938-92-5 N-(2-formylaminoethyl)formamide 
• 100-52-7 benzaldehyde 
• 6274-53-9 N-(2-(phenylsulfonamido)ethyl)acetamide 
• 620-05-3 iodomethylbenzene 
• 107-15-3 ethylenediamine 
• 103-67-3 benzyl-methyl-amine 
• 143722-92-3 N-benzyl-N-(2-formylaminoethyl)formamide 
• 100-39-0 benzyl bromide 
• 100-51-6 benzyl alcohol 
• 174799-52-1 tert-butyl {2-[benzylamino]ethyl}carbamate 
• 936-49-2 2-phenyl-2-imidazoline 
• 100-44-7 benzyl chloride 

Downstream Products

• 107235-83-6 N-Benzyl-N,N'-dibenzoylethylenediamine 
• 67696-34-8 (3-benzyl-2-dimethylamino-[1,3,2]diazaphospholidin-1-yl)-phosphonous acid bis-dimethylamide 
• 51171-27-8 1-benzyl-2-(5-nitro-furan-2-yl)-4,5-dihydro-1H-imidazole 
• 72702-56-8 2--1-phenylethanol 
• 131203-44-6 2-[(2-Benzylamino-ethyl)-(2-hydroxy-2-phenyl-ethyl)-amino]-1-phenyl-ethanol 
• 141856-06-6 N-Benzyl-N'-(triphenylmethyl)ethane-1,2-diamine 
• 316381-49-4 N¹-benzyl-N¹,N²,N²-tris(pyridine-2-ylmethyl)ethane-1,2-diamine 

Relevant articles and documents

Design, Synthesis, and Synergistic Activity of Eight-Membered Oxabridge Neonicotinoid Analogues

Insecticide synergists are sought-after due to their potential in improving the pesticide control efficacy with a reduced dose of an active ingredient. We previously reported that a cis-configuration neonicotinoid (IPPA08) exhibited specific synergistic activity toward neonicotinoid insecticides. In this study, we synthesized a series of structural analogues of IPPA08 by converting the pyridyl moiety of IPPA08 into phenyl groups, via facile double-Mannich condensation reactions between nitromethylene compounds and glutaraldehyde. All of the oxabridged neonicotinoid compounds were found to increase the toxicity of imidacloprid against Aphis craccivora. Notably, compound 25 at 0.75 mg/L lowered the LC50 value of imidacloprid against A. craccivora by 6.54-fold, while a 3.50-fold reduction of the LC50 value was observed for IPPA08. The results of bee toxicity test showed that compound 25 display selectivity in its effects on imidacloprid toxicity against the honey bee (Apis mellifera L.). In summary, replacing the pyridyl ring with a phenyl ring was a viable approach to obtain a novel synergist with oxabridged moiety for neonicotinoid insecticides.

A new kind of acetylcholine esterase inhibitors and its preparation method and application (by machine translation)

The present invention provides a novel acetyl choline esterase inhibitor and its preparation method and application, in particular, the invention discloses a formula A shown with double AChE binding site of substituted acridine compound, and its preparation method and as acetylcholinesterase inhibitors. The preparation of the novel compounds of this invention demonstrate good inhibit acetylcholine esterase role, can be used as a preparation for treating and preventing HAMER (AD) application value. (by machine translation)

Highly enantioselective synthesis of 2,3-dihydro-1 H-imidazo[2,1-a isoindol-5(9b H)-ones via catalytic asymmetric intramolecular cascade imidization-nucleophilic addition-lactamization

Highly enantioselective catalytic asymmetric intramolecular cascade imidization-nucleophilic addition-lactamization of N1-alkylethane-1,2-diamine with methyl 2-formylbenzoate catalyzed by a chiral phosphoric acid represents the first efficient method for the preparation of medicinally interesting chiral 2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-ones with high yields and excellent enantioselectivities. This strategy has been shown to be quite general toward various methyl 2-formylbenzoates.