(S)-di-tert-butyl 1-(2-(((benzyloxy)carbonyl)amino)-1-oxopropan-2-yl)hydrazine-1,2-dicarboxylate

Base Information

Chemical Name:(S)-di-tert-butyl 1-(2-(((benzyloxy)carbonyl)amino)-1-oxopropan-2-yl)hydrazine-1,2-dicarboxylate
CAS No.:1440418-59-6
Molecular Formula:C₂₁H₃₁N₃O₇
Molecular Weight:437.493
Hs Code.:

Synonyms:(S)-di-tert-butyl 1-(2-(((benzyloxy)carbonyl)amino)-1-oxopropan-2-yl)hydrazine-1,2-dicarboxylate

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Chemical Property of (S)-di-tert-butyl 1-(2-(((benzyloxy)carbonyl)amino)-1-oxopropan-2-yl)hydrazine-1,2-dicarboxylate

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Technology Process of (S)-di-tert-butyl 1-(2-(((benzyloxy)carbonyl)amino)-1-oxopropan-2-yl)hydrazine-1,2-dicarboxylate

There total 2 articles about (S)-di-tert-butyl 1-(2-(((benzyloxy)carbonyl)amino)-1-oxopropan-2-yl)hydrazine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 870-50-8
di-tert-butyl-diazodicarboxylate

: 105499-10-3
(1(S)-methyl-2-oxo-ethyl)-carbamic acid benzyl ester

: (R)-di-tert-butyl 1-(2-(((benzyloxy)carbonyl)amino)-1-oxopropan-2-yl)hydrazine-1,2-dicarboxylate

: 1440418-59-6
(S)-di-tert-butyl 1-(2-(((benzyloxy)carbonyl)amino)-1-oxopropan-2-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: With (S)-4-(tert-butoxy)-2-methyl-4-oxobutanoic acid; In tetrahydrofuran; at 0 ℃; for 48h; Overall yield = 74 %; Overall yield = 130 mg; enantioselective reaction;
DOI:10.1016/j.tet.2013.04.103

Reference yield:

: 6429-44-3,61425-27-2,66674-16-6,87905-97-3
benzyl (2-hydroxy-1-methylethyl)-carbamate

: (R)-di-tert-butyl 1-(2-(((benzyloxy)carbonyl)amino)-1-oxopropan-2-yl)hydrazine-1,2-dicarboxylate

: 1440418-59-6
(S)-di-tert-butyl 1-(2-(((benzyloxy)carbonyl)amino)-1-oxopropan-2-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / dimethyl sulfoxide; dichloromethane / 0.25 h / -60 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: (S)-4-(tert-butoxy)-2-methyl-4-oxobutanoic acid / tetrahydrofuran / 48 h / 0 °C

With oxalyl dichloride; (S)-4-(tert-butoxy)-2-methyl-4-oxobutanoic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.tet.2013.04.103