[1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

Base Information

Chemical Name:[1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-morpholin-4-yl-methanone
CAS No.:1574110-28-3
Molecular Formula:C₂₄H₂₂ClF₃N₂O₂
Molecular Weight:462.899
Hs Code.:

Synonyms:[1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

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Chemical Property of [1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

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Technology Process of [1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

There total 6 articles about [1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-morpholin-4-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 2314-97-8,263005-66-9
iodotrifluoromethane

: 1574118-29-8
(1-benzyl-3-(4-chlorophenyl)-4-methyl-1H-pyrrol-2-yl)(morpholino)methanone

: 1574110-28-3
[1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

Guidance literature:: iodotrifluoromethane; (1-benzyl-3-(4-chlorophenyl)-4-methyl-1H-pyrrol-2-yl)(morpholino)methanone; With ferrous(II) sulfate heptahydrate; In dimethyl sulfoxide; for 0.0333333h;

With dihydrogen peroxide; In water; dimethyl sulfoxide; for 1h;

Reference yield:

: 37629-52-0
(E)-1-(4-chlorophenyl)-2-nitropropene

: 1574110-28-3
[1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,5,7-triazabicyclo[4.4.0]dec-5-ene polystyrene / tetrahydrofuran; isopropyl alcohol / 20 °C

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h / 0 °C

2.2: 20 °C

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran; ethanol / 2 h / Reflux

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 20 °C / Cooling with ice

5.1: ferrous(II) sulfate heptahydrate; dihydrogen peroxide / dimethyl sulfoxide; water / 1.03 h

With ferrous(II) sulfate heptahydrate; 1-hydroxy-7-aza-benzotriazole; lithium hydroxide monohydrate; water; dihydrogen peroxide; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;

Reference yield:

: 1574117-15-9
1-benzyl-3-(4-chlorophenyl)-4-methyl-1H-pyrrole-2-carboxylic acid

: 1574110-28-3
[1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 20 °C / Cooling with ice

2: ferrous(II) sulfate heptahydrate; dihydrogen peroxide / dimethyl sulfoxide; water / 1.03 h

With ferrous(II) sulfate heptahydrate; 1-hydroxy-7-aza-benzotriazole; dihydrogen peroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; dimethyl sulfoxide;