1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbaldehyde

Base Information

Chemical Name:1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbaldehyde
CAS No.:1035216-45-5
Molecular Formula:C₂₁H₁₉ClN₂O₃
Molecular Weight:382.846
Hs Code.:

Synonyms:1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbaldehyde

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Chemical Property of 1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbaldehyde

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Technology Process of 1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbaldehyde

There total 3 articles about 1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1035214-76-6
1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbonitrile

: 1035216-45-5
1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbaldehyde

Guidance literature:: 1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbonitrile; With diisobutylaluminium hydride; In dichloromethane; at -40 - 20 ℃;

With methanol; water; rochelle salt; In dichloromethane; at 20 ℃;

Reference yield:

: 915020-91-6
4-(1-cyanocyclopropyl)benzoic acid

: 1035216-45-5
1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: dicyclohexyl-carbodiimide; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / acetonitrile / 0.42 h / 160 °C / microwave irradiation; Sealed tube

2.1: diisobutylaluminium hydride / dichloromethane / -40 - 20 °C

2.2: 20 °C

With diisobutylaluminium hydride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; acetonitrile;

Reference yield:

: 1035216-81-9,1035218-35-9
(Z)-3-chloro-N'-hydroxy-4-isopropoxybenzimidamide

: 1035216-45-5
1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: dicyclohexyl-carbodiimide; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / acetonitrile / 0.42 h / 160 °C / microwave irradiation; Sealed tube

2.1: diisobutylaluminium hydride / dichloromethane / -40 - 20 °C

2.2: 20 °C

With diisobutylaluminium hydride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; acetonitrile;