1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbonitrile

Base Information

Chemical Name:1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbonitrile
CAS No.:1035214-76-6
Molecular Formula:C₂₁H₁₈ClN₃O₂
Molecular Weight:379.846
Hs Code.:

Synonyms:1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbonitrile

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Chemical Property of 1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbonitrile

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Technology Process of 1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbonitrile

There total 1 articles about 1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.8%

: 915020-91-6
4-(1-cyanocyclopropyl)benzoic acid

: 1035216-81-9,1035218-35-9
(Z)-3-chloro-N'-hydroxy-4-isopropoxybenzimidamide

: 1035214-76-6
1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbonitrile

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In acetonitrile; at 160 ℃; for 0.416667h; Microwave irradiation;

Reference yield: 48.0%

: 1035214-76-6
1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbonitrile

: 1035216-45-5
1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbaldehyde

Guidance literature:: 1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbonitrile; With diisobutylaluminium hydride; In dichloromethane; at -40 - 20 ℃;

With methanol; water; rochelle salt; In dichloromethane; at 20 ℃;

Reference yield:

: 1035214-76-6
1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropanecarbonitrile

: 3-((1-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclopropyl)methylamino)propanoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / dichloromethane / -40 - 20 °C

1.2: 20 °C

2.1: acetic acid / methanol / 0.5 h / 20 °C / Sealed tube

2.2: 20 °C

With diisobutylaluminium hydride; acetic acid; In methanol; dichloromethane;