1-iodo-7-methoxyisoquinoline

Base Information

• Chemical Name: 1-iodo-7-methoxyisoquinoline
• CAS No.: 952569-54-9
• Molecular Formula: C₁₀H₈INO
• Molecular Weight: 285.084
• Hs Code.: 2933499090
• Mol file: 952569-54-9.mol

Synonyms:1-iodo-7-methoxyisoquinoline

Chemical Property of 1-iodo-7-methoxyisoquinoline

Chemical Property:

Purity/Quality:

98.5% ^*data from raw suppliers

1-Iodo-7-methoxyisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-iodo-7-methoxyisoquinoline

There total 2 articles about 1-iodo-7-methoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

7-methoxy-2H-isoquinolin-1-one (16027-16-0) → 1-iodo-7-methoxyisoquinoline (952569-54-9)

Guidance literature:

7-methoxy-2H-isoquinolin-1-one; With pyridine; trifluoromethylsulfonic anhydride; In acetonitrile; at 20 ℃; for 2h; Cooling with ice; Inert atmosphere;

With trifluorormethanesulfonic acid; sodium iodide; In acetonitrile; at 20 ℃; Inert atmosphere;

DOI:10.1021/jo400645g

Reference yield: 44.0%

7-methoxyisoquinoline (39989-39-4) → 1-iodo-7-methoxyisoquinoline (952569-54-9)

Guidance literature:

7-methoxyisoquinoline; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; toluene; for 4h;

With iodine; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 1h;

DOI:10.1016/j.ejmech.2019.111865

Reference yield: 100.0%

1-iodo-7-methoxyisoquinoline (952569-54-9) + 2-bromo-4,5-dimethoxyphenylacetonitrile (51655-39-1) → (2-bromo-4,5-dimethoxyphenyl)(7-methoxyisoquinolin-1-yl)acetonitrile (1432725-67-1)

Guidance literature:

With sodium amide; In tetrahydrofuran; Reflux; Inert atmosphere; Cooling with ice;

DOI:10.1021/jo400645g

upstream raw materials:

7-methoxy-2H-isoquinolin-1-one

7-methoxyisoquinoline

Downstream raw materials:

(2-bromophenyl)(7-methoxyisoquinolin-1-yl)methanone

(2-bromo-4,5-dimethoxyphenyl)(7-methoxyisoquinolin-1-yl)methanone

(2-bromo-5-trifluoromethylphenyl)(7-methoxyisoquinolin-1-yl)methanone

(2-bromophenyl)(7-methoxyisoquinolin-1-yl)acetonitrile