1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-4-hydroxy-2-pyrrolidinone

Base Information

Chemical Name:1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-4-hydroxy-2-pyrrolidinone
CAS No.:852880-81-0
Molecular Formula:C₂₂H₂₃Cl₂FN₂O₂
Molecular Weight:437.341
Hs Code.:

Synonyms:1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-4-hydroxy-2-pyrrolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-4-hydroxy-2-pyrrolidinone

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Technology Process of 1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-4-hydroxy-2-pyrrolidinone

There total 1 articles about 1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-4-hydroxy-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852880-80-9
1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-2,4-pyrrolidinedione; hydrochloride salt

: 852880-81-0
1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-4-hydroxy-2-pyrrolidinone

Guidance literature:: 1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-2,4-pyrrolidinedione; hydrochloride salt; With sodium tetrahydroborate; water; In isopropyl alcohol; at 5 - 20 ℃; for 22.75h;

With hydrogenchloride; In water; isopropyl alcohol; pH=1;

With sodium hydroxide; In water; ethyl acetate; isopropyl alcohol; pH=13;

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 852880-81-0
1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-4-hydroxy-2-pyrrolidinone

: 852880-82-1
1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-1-methyl-4-piperidinyl]-4-hydroxy-2-pyrrolidinone

Guidance literature:: formaldehyd; 1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-4-hydroxy-2-pyrrolidinone; In water; at 20 ℃; for 0.0833333h;

With formic acid; In water; at 100 ℃; for 4 - 12h;

With sodium hydroxide; In water; ethyl acetate; pH=9;