1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-2,4-pyrrolidinedione; hydrochloride salt

Base Information

Chemical Name:1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-2,4-pyrrolidinedione; hydrochloride salt
CAS No.:852880-80-9
Molecular Formula:C₂₂H₂₁Cl₂FN₂O₂*ClH
Molecular Weight:471.786
Hs Code.:

Synonyms:1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-2,4-pyrrolidinedione; hydrochloride salt

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Chemical Property of 1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-2,4-pyrrolidinedione; hydrochloride salt

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Technology Process of 1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-2,4-pyrrolidinedione; hydrochloride salt

There total 1 articles about 1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-2,4-pyrrolidinedione; hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852880-79-6
1,1-dimethylethyl 4-{2-{[(3,5-dichlorophenyl)-methyl]-[2-(ethyloxy)-2-oxoethyl]-amino}-1-[(methyloxy)-carbonyl]-2-oxoethyl}-4-(4-fluorophenyl)-1-piperidinecarboxylate

: 852880-80-9
1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-2,4-pyrrolidinedione; hydrochloride salt

Guidance literature:: 1,1-dimethylethyl 4-{2-{[(3,5-dichlorophenyl)-methyl]-[2-(ethyloxy)-2-oxoethyl]-amino}-1-[(methyloxy)-carbonyl]-2-oxoethyl}-4-(4-fluorophenyl)-1-piperidinecarboxylate; In ethanol; tert-butyl methyl ether; at 30 ℃;

With sodium ethanolate; In ethanol; tert-butyl methyl ether; at 0 - 5 ℃; for 0.333333 - 0.666667h;

With hydrogenchloride; water; In tetrahydrofuran; ethanol; tert-butyl methyl ether; at 20 - 106 ℃; pH=1 - 3; Heating / reflux;

Reference yield:

: 852880-80-9
1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-2,4-pyrrolidinedione; hydrochloride salt

: 852880-81-0
1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-4-hydroxy-2-pyrrolidinone

Guidance literature:: 1-[(3,5-dichlorophenyl)methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-2,4-pyrrolidinedione; hydrochloride salt; With sodium tetrahydroborate; water; In isopropyl alcohol; at 5 - 20 ℃; for 22.75h;

With hydrogenchloride; In water; isopropyl alcohol; pH=1;

With sodium hydroxide; In water; ethyl acetate; isopropyl alcohol; pH=13;