3-(4-chlorophenyl)-2-(4-(8-azidooctylphenyl)thiazol-2-ylamino)propionic acid

Base Information

Chemical Name:3-(4-chlorophenyl)-2-(4-(8-azidooctylphenyl)thiazol-2-ylamino)propionic acid
CAS No.:1094765-49-7
Molecular Formula:C₂₆H₃₀ClN₅O₂S
Molecular Weight:512.076
Hs Code.:

Synonyms:3-(4-chlorophenyl)-2-(4-(8-azidooctylphenyl)thiazol-2-ylamino)propionic acid

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Chemical Property of 3-(4-chlorophenyl)-2-(4-(8-azidooctylphenyl)thiazol-2-ylamino)propionic acid

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Technology Process of 3-(4-chlorophenyl)-2-(4-(8-azidooctylphenyl)thiazol-2-ylamino)propionic acid

There total 8 articles about 3-(4-chlorophenyl)-2-(4-(8-azidooctylphenyl)thiazol-2-ylamino)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1027102-03-9
3-(4-chlorophenyl)-2-thioureido-propionic acid

: 1094765-46-4
2-bromo-4'-(8-azido-octyl)acetophenone

: 1094765-49-7
3-(4-chlorophenyl)-2-(4-(8-azidooctylphenyl)thiazol-2-ylamino)propionic acid

Guidance literature:: In N,N-dimethyl-formamide; for 2h; Inert atmosphere;

Reference yield:

: 1027102-02-8
2-[[[(ethoxycarbonyl)amino]thioxomethyl]amino]-3-(4-chlorophenyl)-propionic acid methyl ester

: 1094765-49-7
3-(4-chlorophenyl)-2-(4-(8-azidooctylphenyl)thiazol-2-ylamino)propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; sodium hydroxide / methanol / 0.5 h / Reflux

1.2: pH 3

2.1: N,N-dimethyl-formamide / 2 h / Inert atmosphere

With water; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 10472-97-6
8-phenyloctan-1-ol

: 1094765-49-7
3-(4-chlorophenyl)-2-(4-(8-azidooctylphenyl)thiazol-2-ylamino)propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C

1.2: 2 h / 0 °C

2.1: triethylamine / dichloromethane / 1 h / Inert atmosphere

3.1: sodium azide / N,N-dimethyl-formamide / 12 h / 80 °C

4.1: copper(ll) bromide / chloroform; ethyl acetate / Reflux

5.1: N,N-dimethyl-formamide / 2 h / Inert atmosphere

With aluminum (III) chloride; sodium azide; triethylamine; copper(ll) bromide; In dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide;