(3S)-tert-butyl 3-(acetylthiomethyl)-4-(2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxyethyl)piperazine-1-carboxylate

Base Information

Chemical Name:(3S)-tert-butyl 3-(acetylthiomethyl)-4-(2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxyethyl)piperazine-1-carboxylate
CAS No.:1426071-35-3
Molecular Formula:C₂₂H₃₀FN₃O₄S
Molecular Weight:451.562
Hs Code.:

Synonyms:(3S)-tert-butyl 3-(acetylthiomethyl)-4-(2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxyethyl)piperazine-1-carboxylate

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Chemical Property of (3S)-tert-butyl 3-(acetylthiomethyl)-4-(2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxyethyl)piperazine-1-carboxylate

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Technology Process of (3S)-tert-butyl 3-(acetylthiomethyl)-4-(2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxyethyl)piperazine-1-carboxylate

There total 16 articles about (3S)-tert-butyl 3-(acetylthiomethyl)-4-(2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxyethyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426071-25-1
tert-butyl (3S)-4-[2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxyethyl]-3-(hydroxymethyl)piperazine-1-carboxylate

: 10387-40-3
potassium thioacetate

: 1426071-35-3
(3S)-tert-butyl 3-(acetylthiomethyl)-4-(2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxyethyl)piperazine-1-carboxylate

Guidance literature:: tert-butyl (3S)-4-[2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxyethyl]-3-(hydroxymethyl)piperazine-1-carboxylate; With dmap; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; for 2h;

potassium thioacetate; In tetrahydrofuran; at 20 - 45 ℃; for 2h; Inert atmosphere;

Reference yield:

: C₂₀H₂₈FN₃O₆S

: 10387-40-3
potassium thioacetate

: 1426071-35-3
(3S)-tert-butyl 3-(acetylthiomethyl)-4-(2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxyethyl)piperazine-1-carboxylate

Guidance literature:: In dimethyl sulfoxide; at 20 - 45 ℃; Inert atmosphere;

Reference yield:

: 198633-76-0
2-fluoro-6-methyl-benzonitrile

: 1426071-35-3
(3S)-tert-butyl 3-(acetylthiomethyl)-4-(2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxyethyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / trifluorormethanesulfonic acid / 1 h / 20 °C

2.1: triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethanol / 4 h / Reflux

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 72 h / 20 °C

4.1: ethanol / 0.5 h / 150 °C / Microwave irradiation

5.1: triethylamine; methanesulfonyl chloride; dmap / tetrahydrofuran / 2 h

5.2: 2 h / 20 - 45 °C / Inert atmosphere

With dmap; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; methanesulfonyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane; trifluorormethanesulfonic acid;