2-FLUORO-6-METHYLBENZONITRILE

Base Information

• Chemical Name: 2-FLUORO-6-METHYLBENZONITRILE
• CAS No.: 198633-76-0
• Molecular Formula: C8H6FN
• Molecular Weight: 135.141
• Hs Code.: 2926909090
• Mol file: 198633-76-0.mol

Synonyms:6-Fluoro-o-tolunitrile;

Chemical Property of 2-FLUORO-6-METHYLBENZONITRILE

Chemical Property:

• Vapor Pressure: 0.226mmHg at 25°C
• Melting Point: 39-46 °C
• Refractive Index: 1.507
• Boiling Point: 207.4 °C at 760 mmHg
• Flash Point: 85.2 °C
• PSA: 23.79000
• Density: 1.12 g/cm³
• LogP: 2.00578
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

2-Fluoro-6-methylbenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUORO-6-METHYLBENZONITRILE

There total 5 articles about 2-FLUORO-6-METHYLBENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-chloro-6-methyl-benzonitrile (6575-09-3) → 2-fluoro-6-methyl-benzonitrile (198633-76-0)

Guidance literature:

With cesium fluoride; In dimethyl sulfoxide;

Reference yield:

zinc(II) cyanide (557-21-1) + 1-fluoro-2-iodo-3-methylbenzene (883502-14-5) → 2-fluoro-6-methyl-benzonitrile (198633-76-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl acetamide; at 80 ℃; for 16h; Inert atmosphere;

Reference yield:

zinc cyanide + 1-fluoro-2-iodo-3-methylbenzene (883502-14-5) → 2-fluoro-6-methyl-benzonitrile (198633-76-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl acetamide; at 80 ℃; for 16h; Inert atmosphere;

upstream raw materials:

2-chloro-6-methyl-benzonitrile

2-Fluorobenzaldehyde

methyl iodide

zinc(II) cyanide

Downstream raw materials:

3-((3R,9aS)-8-((R)-5-( 1H-tetrazol-1-yl)-2,3-dihydro-1H-indene-1-carbonyl)octahydropyrazino[2,1-c][1,4]oxazin-3-yl)-6-fluoro-2-methylbenzonitrile

3-((3R,9aS)-8-((S)-5-(1H-tetrazol-1-yl)-2,3-dihydro-1H-indene-1-carbonyl)octahydropyrazino[2,1-c][1,4]oxazin-3-yl)-6-fluoro-2-methylbenzonitrile

6-fluoro-2-methyl-3-[(3R,9aS)-octahydropyrazino[2,1-c][1,4]oxazin-3-yl]benzonitrile 2,2,2-trifluoroacetate

8-methyl-3-phenylisoquinolin-1-amine

Refernces

• 1、 -. "INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL". Page/Page column 54; 57. . Retrieved 2014/07/08.
• 2、 -. "INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL". Page/Page column 39. . Retrieved 2013/05/21.