5α-hydroxy-3α-p-phenylbenzoyloxy-2β-(3-oxo-octanyl)-1α-cyclopentane acetic acid γ-lactone ethylene dithioketal

Base Information

Chemical Name:5α-hydroxy-3α-p-phenylbenzoyloxy-2β-(3-oxo-octanyl)-1α-cyclopentane acetic acid γ-lactone ethylene dithioketal
CAS No.:122220-90-0
Molecular Formula:C₃₀H₃₆O₄S₂
Molecular Weight:524.745
Hs Code.:

Synonyms:5α-hydroxy-3α-p-phenylbenzoyloxy-2β-(3-oxo-octanyl)-1α-cyclopentane acetic acid γ-lactone ethylene dithioketal

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Chemical Property of 5α-hydroxy-3α-p-phenylbenzoyloxy-2β-(3-oxo-octanyl)-1α-cyclopentane acetic acid γ-lactone ethylene dithioketal

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Technology Process of 5α-hydroxy-3α-p-phenylbenzoyloxy-2β-(3-oxo-octanyl)-1α-cyclopentane acetic acid γ-lactone ethylene dithioketal

There total 2 articles about 5α-hydroxy-3α-p-phenylbenzoyloxy-2β-(3-oxo-octanyl)-1α-cyclopentane acetic acid γ-lactone ethylene dithioketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 540-63-6
ethane-1,2-dithiol

: 42743-32-8
Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-2-oxo-4-(3-oxo-octyl)-hexahydro-cyclopenta[b]furan-5-yl ester

: 122220-90-0
5α-hydroxy-3α-p-phenylbenzoyloxy-2β-(3-oxo-octanyl)-1α-cyclopentane acetic acid γ-lactone ethylene dithioketal

Guidance literature:: With zinc trifluoromethanesulfonate; In dichloromethane; for 2h; Ambient temperature;

Reference yield:

: 31753-00-1
[1,1'-bisphenyl]-4-carboxylic acid (3aR,4R,5R,6aS)-hexahydro-2-oxo-4-[(1E)-3-oxo-1-octen-1-yl]-2H-cyclopenta[b]furan-5-yl ester

: 122220-90-0
5α-hydroxy-3α-p-phenylbenzoyloxy-2β-(3-oxo-octanyl)-1α-cyclopentane acetic acid γ-lactone ethylene dithioketal

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / H₂ / Pd/C / ethyl acetate / 4 h

2: 82 percent / zinc triflate / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogen; zinc trifluoromethanesulfonate; palladium on activated charcoal; In dichloromethane; ethyl acetate;

Reference yield:

: 122220-90-0
5α-hydroxy-3α-p-phenylbenzoyloxy-2β-(3-oxo-octanyl)-1α-cyclopentane acetic acid γ-lactone ethylene dithioketal

: 107615-77-0,191919-02-5
9α-11β-dihydroxy-15-oxo-Z-prost-5-ene-1-oic acid

Guidance literature:: Multi-step reaction with 11 steps

1: 89 percent / methanolic t-BuOK / methyl acetate / 2 h / Ambient temperature

2: 80 percent / p-toluenesulfonic acid / CH₂Cl₂ / 1 h / Ambient temperature

3: 94 percent / DIBAL / tetrahydrofuran / 0.5 h / -78 °C

4: 1.) lithium bis(trimethylsilyl)amide, HMPA / 1.) THF, 0 deg C, 30 min, 2.) THF, -40 -> 0 deg C, 30 min

6: 80 percent / CH₂Cl₂ / 0.5 h / 0 °C

7: 88 percent / cation exchange resin AG₅₀-X₈ / methanol / 6 h / 23 °C

8: triethylamine / CH₂Cl₂ / 0.5 h / -20 °C

9: 18-crown-6-ether / toluene / 8 h / 115 °C

10: 71 percent / aq. ceric ammonium nitrate / acetonitrile / 1 h / Ambient temperature

11: aq. LiOH / 1,2-dimethoxy-ethane / 1 h / 60 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hydroxide; ammonium cerium(IV) nitrate; 18-crown-6 ether; cation exchange resin AG₅₀-X₈; potassium tert-butylate; diisobutylaluminium hydride; toluene-4-sulfonic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; acetic acid methyl ester; toluene; acetonitrile;