N⁶-acetyl-N²-benzyloxycarbonyl-N⁶-L-hydroxylysine tert-butyl ester

Base Information

• Chemical Name: N⁶-acetyl-N²-benzyloxycarbonyl-N⁶-L-hydroxylysine tert-butyl ester
• CAS No.: 112157-43-4
• Molecular Formula: C₂₀H₃₀N₂O₆
• Molecular Weight: 394.468
• Mol file: 112157-43-4.mol

Synonyms:N⁶-acetyl-N²-benzyloxycarbonyl-N⁶-L-hydroxylysine tert-butyl ester

Chemical Property of N⁶-acetyl-N²-benzyloxycarbonyl-N⁶-L-hydroxylysine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N⁶-acetyl-N²-benzyloxycarbonyl-N⁶-L-hydroxylysine tert-butyl ester

There total 3 articles about N⁶-acetyl-N²-benzyloxycarbonyl-N⁶-L-hydroxylysine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-6-(Acetyl-benzoyloxy-amino)-2-benzyloxycarbonylamino-hexanoic acid tert-butyl ester (112157-40-1) → N6-acetyl-N2-benzyloxycarbonyl-N6-L-hydroxylysine tert-butyl ester (112157-43-4)

Guidance literature:

With ammonium hydroxide; In methanol;

DOI:10.1016/S0040-4039(00)95430-3

Reference yield:

acetic acid tert-butyl ester (540-88-5) → N6-acetyl-N2-benzyloxycarbonyl-N6-L-hydroxylysine tert-butyl ester (112157-43-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 58 percent / HClO₄

2: 1.) Na₂CO₃, 2.) base / 1.) CH₂Cl₂, 2.) H₂O

3: 90 percent / 10percent NH₃ / methanol

With ammonium hydroxide; perchloric acid; sodium carbonate; In methanol;

DOI:10.1016/S0040-4039(00)95430-3

Reference yield:

(S)-6-Amino-2-phenylacetylamino-hexanoic acid tert-butyl ester → N6-acetyl-N2-benzyloxycarbonyl-N6-L-hydroxylysine tert-butyl ester (112157-43-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Na₂CO₃, 2.) base / 1.) CH₂Cl₂, 2.) H₂O

2: 90 percent / 10percent NH₃ / methanol

With ammonium hydroxide; sodium carbonate; In methanol;

DOI:10.1016/S0040-4039(00)95430-3

upstream raw materials:

(S)-6-(Acetyl-benzoyloxy-amino)-2-benzyloxycarbonylamino-hexanoic acid tert-butyl ester

acetic acid tert-butyl ester

Downstream raw materials:

N^ε-Acetyl-N^ε-hydroxy-N^α-L-lysine