(S)-6-(Acetyl-benzoyloxy-amino)-2-benzyloxycarbonylamino-hexanoic acid tert-butyl ester

Base Information

• Chemical Name: (S)-6-(Acetyl-benzoyloxy-amino)-2-benzyloxycarbonylamino-hexanoic acid tert-butyl ester
• CAS No.: 112157-40-1
• Molecular Formula: C₂₇H₃₄N₂O₇
• Molecular Weight: 498.576
• Mol file: 112157-40-1.mol

Synonyms:(S)-6-(Acetyl-benzoyloxy-amino)-2-benzyloxycarbonylamino-hexanoic acid tert-butyl ester

Chemical Property of (S)-6-(Acetyl-benzoyloxy-amino)-2-benzyloxycarbonylamino-hexanoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-6-(Acetyl-benzoyloxy-amino)-2-benzyloxycarbonylamino-hexanoic acid tert-butyl ester

There total 2 articles about (S)-6-(Acetyl-benzoyloxy-amino)-2-benzyloxycarbonylamino-hexanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic acid tert-butyl ester (540-88-5) → (S)-6-(Acetyl-benzoyloxy-amino)-2-benzyloxycarbonylamino-hexanoic acid tert-butyl ester (112157-40-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / HClO₄

2: 1.) Na₂CO₃, 2.) base / 1.) CH₂Cl₂, 2.) H₂O

With perchloric acid; sodium carbonate;

DOI:10.1016/S0040-4039(00)95430-3

Reference yield:

(S)-6-Amino-2-phenylacetylamino-hexanoic acid tert-butyl ester + acetyl chloride (75-36-5) + dibenzoyl peroxide (94-36-0) → (S)-6-Benzoylamino-2-benzyloxycarbonylamino-hexanoic acid tert-butyl ester (112157-41-2) + (S)-6-(Acetyl-benzoyloxy-amino)-2-benzyloxycarbonylamino-hexanoic acid tert-butyl ester (112157-40-1)

Guidance literature:

With sodium carbonate; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₂Cl₂, 2.) H₂O;

DOI:10.1016/S0040-4039(00)95430-3

Reference yield: 90.0%

(S)-6-(Acetyl-benzoyloxy-amino)-2-benzyloxycarbonylamino-hexanoic acid tert-butyl ester (112157-40-1) → N6-acetyl-N2-benzyloxycarbonyl-N6-L-hydroxylysine tert-butyl ester (112157-43-4)

Guidance literature:

With ammonium hydroxide; In methanol;

DOI:10.1016/S0040-4039(00)95430-3

upstream raw materials:

acetyl chloride

dibenzoyl peroxide

acetic acid tert-butyl ester

Downstream raw materials:

N⁶-acetyl-N²-benzyloxycarbonyl-N⁶-L-hydroxylysine tert-butyl ester

N^ε-Acetyl-N^ε-hydroxy-N^α-L-lysine

N^ε-Acetyl-N^ε-hydroxy-N^α-(carbobenzyloxy)-L-lysine