Acetic acid (2R,3S,6S)-2-acetoxymethyl-6-{(R)-1-[(3R,4S)-1-(4-methoxy-phenyl)-2-oxo-4-phenyl-azetidin-3-yl]-ethoxy}-3,6-dihydro-2H-pyran-3-yl ester

Base Information

Chemical Name:Acetic acid (2R,3S,6S)-2-acetoxymethyl-6-{(R)-1-[(3R,4S)-1-(4-methoxy-phenyl)-2-oxo-4-phenyl-azetidin-3-yl]-ethoxy}-3,6-dihydro-2H-pyran-3-yl ester
CAS No.:205518-58-7
Molecular Formula:C₂₈H₃₁NO₈
Molecular Weight:509.556
Hs Code.:

Synonyms:Acetic acid (2R,3S,6S)-2-acetoxymethyl-6-{(R)-1-[(3R,4S)-1-(4-methoxy-phenyl)-2-oxo-4-phenyl-azetidin-3-yl]-ethoxy}-3,6-dihydro-2H-pyran-3-yl ester

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Chemical Property of Acetic acid (2R,3S,6S)-2-acetoxymethyl-6-{(R)-1-[(3R,4S)-1-(4-methoxy-phenyl)-2-oxo-4-phenyl-azetidin-3-yl]-ethoxy}-3,6-dihydro-2H-pyran-3-yl ester

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Technology Process of Acetic acid (2R,3S,6S)-2-acetoxymethyl-6-{(R)-1-[(3R,4S)-1-(4-methoxy-phenyl)-2-oxo-4-phenyl-azetidin-3-yl]-ethoxy}-3,6-dihydro-2H-pyran-3-yl ester

There total 3 articles about Acetic acid (2R,3S,6S)-2-acetoxymethyl-6-{(R)-1-[(3R,4S)-1-(4-methoxy-phenyl)-2-oxo-4-phenyl-azetidin-3-yl]-ethoxy}-3,6-dihydro-2H-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 100239-17-6,100296-90-0,100296-91-1,106399-72-8,106399-73-9,106399-74-0
cis-3-(1-hydroxyethyl)-4-phenyl-N-p-anisyl-2-azetidinone

: 2873-29-2
D-glucal triacetate

: 1198298-98-4
C₂₈H₃₁NO₈

: 205518-58-7
Acetic acid (2R,3S,6S)-2-acetoxymethyl-6-{(R)-1-[(3R,4S)-1-(4-methoxy-phenyl)-2-oxo-4-phenyl-azetidin-3-yl]-ethoxy}-3,6-dihydro-2H-pyran-3-yl ester

Guidance literature:: With iodine; In tetrahydrofuran; at 20 ℃; for 40h; stereoselective reaction;
DOI:10.3987/COM-09-11729

Reference yield:

: 783-08-4
[4-(benzylideneamino)phenyl]methanol

: 205518-58-7
Acetic acid (2R,3S,6S)-2-acetoxymethyl-6-{(R)-1-[(3R,4S)-1-(4-methoxy-phenyl)-2-oxo-4-phenyl-azetidin-3-yl]-ethoxy}-3,6-dihydro-2H-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / LDA / tetrahydrofuran / 3 h / -20 °C

2: I₂ / tetrahydrofuran / 24 h / Ambient temperature

With iodine; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.3987/com-97-s66

Reference yield:

: 100239-17-6,100296-90-0,100296-91-1,106399-72-8,106399-73-9,106399-74-0
cis-3-(1-hydroxyethyl)-4-phenyl-N-p-anisyl-2-azetidinone

: 2873-29-2
D-glucal triacetate

: 205518-58-7
Acetic acid (2R,3S,6S)-2-acetoxymethyl-6-{(R)-1-[(3R,4S)-1-(4-methoxy-phenyl)-2-oxo-4-phenyl-azetidin-3-yl]-ethoxy}-3,6-dihydro-2H-pyran-3-yl ester

: Acetic acid (2R,3S,6S)-2-acetoxymethyl-6-{(S)-1-[(3S,4R)-1-(4-methoxy-phenyl)-2-oxo-4-phenyl-azetidin-3-yl]-ethoxy}-3,6-dihydro-2H-pyran-3-yl ester

Guidance literature:: With iodine; In tetrahydrofuran; for 24h; Yield given. Yields of byproduct given; Ambient temperature;
DOI:10.3987/com-97-s66