methyl 4-<2-<<1-<5-chloro-2-(3,5-cis-dimethyl-1-piperidinyl)phenyl>ethyl>amino>-2-oxoethyl>-benzoate

Base Information

Chemical Name:methyl 4-<2-<<1-<5-chloro-2-(3,5-cis-dimethyl-1-piperidinyl)phenyl>ethyl>amino>-2-oxoethyl>-benzoate
CAS No.:219922-14-2
Molecular Formula:C₂₅H₃₁ClN₂O₃
Molecular Weight:442.986
Hs Code.:

Synonyms:methyl 4-<2-<<1-<5-chloro-2-(3,5-cis-dimethyl-1-piperidinyl)phenyl>ethyl>amino>-2-oxoethyl>-benzoate

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Chemical Property of methyl 4-<2-<<1-<5-chloro-2-(3,5-cis-dimethyl-1-piperidinyl)phenyl>ethyl>amino>-2-oxoethyl>-benzoate

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Technology Process of methyl 4-<2-<<1-<5-chloro-2-(3,5-cis-dimethyl-1-piperidinyl)phenyl>ethyl>amino>-2-oxoethyl>-benzoate

There total 12 articles about methyl 4-<2-<<1-<5-chloro-2-(3,5-cis-dimethyl-1-piperidinyl)phenyl>ethyl>amino>-2-oxoethyl>-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99-75-2
4-methyl-benzoic acid methyl ester

: 219922-14-2
methyl 4-<2-<<1-<5-chloro-2-(3,5-cis-dimethyl-1-piperidinyl)phenyl>ethyl>amino>-2-oxoethyl>-benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / N-bromosuccinimide, dibenzoyl-peroxide / CCl₄ / 2.5 h / Heating

2: 54 percent / dimethylsulfoxide / 2 h / 40 °C

3: HCl / 8 h / Heating

4: aq. NaHCO₃ / diethyl ether

5: 74 percent / NaOH / methanol / 4 h / 50 °C

6: 1.) N,N'-carbonyldiimidazole / 1.) THF, reflux, 1 h, 2.) THF, RT, overnight

With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; sodium hydrogencarbonate; 1,1'-carbonyldiimidazole; dibenzoyl peroxide; In methanol; tetrachloromethane; diethyl ether; dimethyl sulfoxide;
DOI:10.1021/jm9810349

Reference yield:

: 14446-75-4,32410-46-1,32452-46-3,35794-11-7
(3S,5R)-3,5-dimethylpiperidine

: 219922-14-2
methyl 4-<2-<<1-<5-chloro-2-(3,5-cis-dimethyl-1-piperidinyl)phenyl>ethyl>amino>-2-oxoethyl>-benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 2 h / Heating

2: Fe, aq. NH₄Cl / 2 h / Heating

3: 1.) aq. NaNO₂, HCl, 2.) Cu₂Cl₂, HCl / 1.) 0 deg C, 2.) 40 deg C, 2 h

4: diethyl ether / 94 h / Heating

5: LiAlH₄ / diethyl ether / 4 h / Heating

6: 1.) N,N'-carbonyldiimidazole / 1.) THF, reflux, 1 h, 2.) THF, RT, overnight

With copper(I) chloride; hydrogenchloride; lithium aluminium tetrahydride; iron; ammonium chloride; 1,1'-carbonyldiimidazole; sodium nitrite; In diethyl ether; ethanol;
DOI:10.1021/jm9810349

Reference yield:

: 16588-02-6
4-chloro-3-cyanonitrobenzene

: 219922-14-2
methyl 4-<2-<<1-<5-chloro-2-(3,5-cis-dimethyl-1-piperidinyl)phenyl>ethyl>amino>-2-oxoethyl>-benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 2 h / Heating

2: Fe, aq. NH₄Cl / 2 h / Heating

3: 1.) aq. NaNO₂, HCl, 2.) Cu₂Cl₂, HCl / 1.) 0 deg C, 2.) 40 deg C, 2 h

4: diethyl ether / 94 h / Heating

5: LiAlH₄ / diethyl ether / 4 h / Heating

6: 1.) N,N'-carbonyldiimidazole / 1.) THF, reflux, 1 h, 2.) THF, RT, overnight

With copper(I) chloride; hydrogenchloride; lithium aluminium tetrahydride; iron; ammonium chloride; 1,1'-carbonyldiimidazole; sodium nitrite; In diethyl ether; ethanol;
DOI:10.1021/jm9810349