4-[5-benzyl-3-(4-iodophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]-N'-hydroxybenzimidamide

Base Information

• Chemical Name: 4-[5-benzyl-3-(4-iodophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]-N'-hydroxybenzimidamide
• CAS No.: 1313055-17-2
• Molecular Formula: C₂₅H₂₃IN₂O₄S
• Molecular Weight: 574.439
• Mol file: 1313055-17-2.mol

Synonyms:4-[5-benzyl-3-(4-iodophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]-N'-hydroxybenzimidamide

Chemical Property of 4-[5-benzyl-3-(4-iodophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]-N'-hydroxybenzimidamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[5-benzyl-3-(4-iodophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]-N'-hydroxybenzimidamide

There total 4 articles about 4-[5-benzyl-3-(4-iodophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]-N'-hydroxybenzimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-[5-benzyl-3-(4-iodophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]benzonitrile (1313055-05-8) → 4-[5-benzyl-3-(4-iodophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]-N'-hydroxybenzimidamide (1313055-17-2)

Guidance literature:

With hydroxylamine hydrochloride; potassium tert-butylate; In dimethyl sulfoxide; at 5 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.04.026

Reference yield:

4-Cyanophenacyl bromide (20099-89-2) → 4-[5-benzyl-3-(4-iodophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]-N'-hydroxybenzimidamide (1313055-17-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate; sodium sulfite / water / 0.33 h / 100 °C / Microwave irradiation

1.2: 0.17 h / 100 °C / Microwave irradiation

2.1: copper diacetate; manganese(III) triacetate dihydrate; acetic acid / 0.75 h / 50 - 80 °C / Microwave irradiation

3.1: hydroxylamine hydrochloride; potassium tert-butylate / dimethyl sulfoxide / 12 h / 5 - 20 °C / Inert atmosphere

With hydroxylamine hydrochloride; potassium tert-butylate; copper diacetate; manganese(III) triacetate dihydrate; sodium hydrogencarbonate; acetic acid; sodium sulfite; In water; dimethyl sulfoxide;

DOI:10.1016/j.ejmech.2011.04.026

Reference yield:

4-[2-(4-iodophenylsulfonyl)acetyl]benzonitrile (1313054-94-2) → 4-[5-benzyl-3-(4-iodophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]-N'-hydroxybenzimidamide (1313055-17-2)

Guidance literature:

Multi-step reaction with 2 steps

1: copper diacetate; manganese(III) triacetate dihydrate; acetic acid / 0.75 h / 50 - 80 °C / Microwave irradiation

2: hydroxylamine hydrochloride; potassium tert-butylate / dimethyl sulfoxide / 12 h / 5 - 20 °C / Inert atmosphere

With hydroxylamine hydrochloride; potassium tert-butylate; copper diacetate; manganese(III) triacetate dihydrate; acetic acid; In dimethyl sulfoxide;

DOI:10.1016/j.ejmech.2011.04.026

upstream raw materials:

4-[5-benzyl-3-(4-iodophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]benzonitrile

4-[2-(4-iodophenylsulfonyl)acetyl]benzonitrile

4-Cyanophenacyl bromide

p-Iodobenzenesulfonyl chloride