4-[2-(4-iodophenylsulfonyl)acetyl]benzonitrile

Base Information

• Chemical Name: 4-[2-(4-iodophenylsulfonyl)acetyl]benzonitrile
• CAS No.: 1313054-94-2
• Molecular Formula: C₁₅H₁₀INO₃S
• Molecular Weight: 411.22
• Mol file: 1313054-94-2.mol

Synonyms:4-[2-(4-iodophenylsulfonyl)acetyl]benzonitrile

Chemical Property of 4-[2-(4-iodophenylsulfonyl)acetyl]benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-[2-(4-iodophenylsulfonyl)acetyl]benzonitrile

There total 1 articles about 4-[2-(4-iodophenylsulfonyl)acetyl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-Cyanophenacyl bromide (20099-89-2) + p-Iodobenzenesulfonyl chloride (98-61-3) → 4-[2-(4-iodophenylsulfonyl)acetyl]benzonitrile (1313054-94-2)

Guidance literature:

p-Iodobenzenesulfonyl chloride; With sodium hydrogencarbonate; sodium sulfite; In water; at 100 ℃; for 0.333333h; Microwave irradiation;

4-Cyanophenacyl bromide; In ethanol; water; at 100 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1016/j.ejmech.2011.04.026

Reference yield: 52.0%

2-methyl-1-phenyl-2-propene (3290-53-7) + 4-[2-(4-iodophenylsulfonyl)acetyl]benzonitrile (1313054-94-2) → 4-[5-benzyl-3-(4-iodophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]benzonitrile (1313055-05-8)

Guidance literature:

With copper diacetate; manganese(III) triacetate dihydrate; acetic acid; at 50 - 80 ℃; for 0.75h; Microwave irradiation;

DOI:10.1016/j.ejmech.2011.04.026

Reference yield:

4-[2-(4-iodophenylsulfonyl)acetyl]benzonitrile (1313054-94-2) → 4-[5-benzyl-3-(4-iodophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]-N'-hydroxybenzimidamide (1313055-17-2)

Guidance literature:

Multi-step reaction with 2 steps

1: copper diacetate; manganese(III) triacetate dihydrate; acetic acid / 0.75 h / 50 - 80 °C / Microwave irradiation

2: hydroxylamine hydrochloride; potassium tert-butylate / dimethyl sulfoxide / 12 h / 5 - 20 °C / Inert atmosphere

With hydroxylamine hydrochloride; potassium tert-butylate; copper diacetate; manganese(III) triacetate dihydrate; acetic acid; In dimethyl sulfoxide;

DOI:10.1016/j.ejmech.2011.04.026

upstream raw materials:

4-Cyanophenacyl bromide

p-Iodobenzenesulfonyl chloride

Downstream raw materials:

4-[5-benzyl-3-(4-iodophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]-N'-hydroxybenzimidamide

4-[5-benzyl-3-(4-iodophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]benzonitrile