(S,S,S)-cyclohexane-cis,cis-1,3,5-tricarboxylic acid tris(1-carboxy-2-phenylethyl)amide

Base Information

• Chemical Name: (S,S,S)-cyclohexane-cis,cis-1,3,5-tricarboxylic acid tris(1-carboxy-2-phenylethyl)amide
• CAS No.: 613243-61-1
• Molecular Formula: C₃₆H₃₉N₃O₉
• Molecular Weight: 657.72
• Mol file: 613243-61-1.mol

Synonyms:(S,S,S)-cyclohexane-cis,cis-1,3,5-tricarboxylic acid tris(1-carboxy-2-phenylethyl)amide

Chemical Property of (S,S,S)-cyclohexane-cis,cis-1,3,5-tricarboxylic acid tris(1-carboxy-2-phenylethyl)amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S,S,S)-cyclohexane-cis,cis-1,3,5-tricarboxylic acid tris(1-carboxy-2-phenylethyl)amide

There total 4 articles about (S,S,S)-cyclohexane-cis,cis-1,3,5-tricarboxylic acid tris(1-carboxy-2-phenylethyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

(S)-2-{[3,5-Bis-((S)-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-cyclohexanecarbonyl]-amino}-3-phenyl-propionic acid methyl ester (613243-60-0) → (S,S,S)-cyclohexane-cis,cis-1,3,5-tricarboxylic acid tris(1-carboxy-2-phenylethyl)amide (613243-61-1)

Guidance literature:

With sodium hydroxide; In methanol; water; at 0 - 20 ℃; for 20h;

DOI:10.1039/c7cc00017k

Reference yield:

(1S,3S,5S)-cyclohexane-1,3,5-tricarbonyl trichloride (147365-19-3) → (S,S,S)-cyclohexane-cis,cis-1,3,5-tricarboxylic acid tris(1-carboxy-2-phenylethyl)amide (613243-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 0 - 20 °C

2: aq. NaOH / methanol / 2 h / 20 °C

With sodium hydroxide; triethylamine; In methanol; dichloromethane;

DOI:10.1021/ja036954h

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → (S,S,S)-cyclohexane-cis,cis-1,3,5-tricarboxylic acid tris(1-carboxy-2-phenylethyl)amide (613243-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 0 - 20 °C

2: aq. NaOH / methanol / 2 h / 20 °C

With sodium hydroxide; triethylamine; In methanol; dichloromethane;

DOI:10.1021/ja036954h

upstream raw materials:

(S)-2-{[3,5-Bis-((S)-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-cyclohexanecarbonyl]-amino}-3-phenyl-propionic acid methyl ester

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

(1S,3S,5S)-cyclohexane-1,3,5-tricarbonyl trichloride

cis-1,3,5-cyclohexane tricarboxylic acid