(4-fluorophenyl)[4-(pyrrolidin-1-ylmethyl)phenyl](7-chloroquinolin-4-yl)methanol

Base Information

• Chemical Name: (4-fluorophenyl)[4-(pyrrolidin-1-ylmethyl)phenyl](7-chloroquinolin-4-yl)methanol
• CAS No.: 1014987-09-7
• Molecular Formula: C₂₇H₂₄ClFN₂O
• Molecular Weight: 446.952

Synonyms:(4-fluorophenyl)[4-(pyrrolidin-1-ylmethyl)phenyl](7-chloroquinolin-4-yl)methanol

Chemical Property of (4-fluorophenyl)[4-(pyrrolidin-1-ylmethyl)phenyl](7-chloroquinolin-4-yl)methanol

Chemical Property:

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Technology Process of (4-fluorophenyl)[4-(pyrrolidin-1-ylmethyl)phenyl](7-chloroquinolin-4-yl)methanol

There total 2 articles about (4-fluorophenyl)[4-(pyrrolidin-1-ylmethyl)phenyl](7-chloroquinolin-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

N-(p-bromobenzyl)pyrrolidine (4897-55-6) + (7-chloroquinolin-4-yl)(4-fluorophenyl)methanone (169957-16-8) → (4-fluorophenyl)[4-(pyrrolidin-1-ylmethyl)phenyl](7-chloroquinolin-4-yl)methanol (1014987-09-7)

Guidance literature:

N-(p-bromobenzyl)pyrrolidine; With magnesium; iodine; In tetrahydrofuran;

(7-chloroquinolin-4-yl)(4-fluorophenyl)methanone; In tetrahydrofuran; at 75 ℃; for 6h; Further stages.;

DOI:10.1021/jm701247k

Reference yield: 40.0%

→ (4-fluorophenyl)[4-(pyrrolidin-1-ylmethyl)phenyl](7-chloroquinolin-4-yl)methanol (1014987-09-7)

Guidance literature:

Reference yield:

(4-fluorophenyl)[4-(pyrrolidin-1-ylmethyl)phenyl](7-chloroquinolin-4-yl)methanol (1014987-09-7) → C27H23Cl2FN2

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 45 ℃; for 4.33333h;

DOI:10.1021/jm701247k

upstream raw materials:

N-(p-bromobenzyl)pyrrolidine

(7-chloroquinolin-4-yl)(4-fluorophenyl)methanone

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