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4897-55-6

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4897-55-6 Usage

Description

Pyrrolidine, 1-[(4-bromophenyl)methyl]is a chemical compound belonging to the pyrrolidine class, characterized by a pyrrolidine ring structure with a 4-bromophenylmethyl substituent. With the molecular formula C11H14BrN, this compound is utilized in various scientific and industrial applications due to its unique structure and reactivity.

Uses

Used in Organic Synthesis:
Pyrrolidine, 1-[(4-bromophenyl)methyl]is used as a building block in organic synthesis for the creation of various pharmaceutical compounds and agrochemicals. Its distinctive structure and reactivity contribute to the development of new chemicals with potential applications in medicine and agriculture.
Used in Pharmaceutical Research:
In Pharmaceutical Research, Pyrrolidine, 1-[(4-bromophenyl)methyl]serves as a key intermediate for the synthesis of medicinal compounds. Its unique properties allow researchers to explore its potential in the development of new drugs with improved therapeutic effects.
Used in Agrochemical Development:
Pyrrolidine, 1-[(4-bromophenyl)methyl]is also utilized in the agrochemical industry as a precursor for the synthesis of pesticides and other agricultural chemicals. Its role in this industry is crucial for enhancing crop protection and yield.
Used in Material Science:
Pyrrolidine, 1-[(4-bromophenyl)methyl]may have potential applications in material science, where its unique structure could contribute to the development of new materials with specific properties for various uses.
Used in Chemical Engineering:
In Chemical Engineering, Pyrrolidine, 1-[(4-bromophenyl)methyl]could be employed in the design and synthesis of novel chemical processes and products, taking advantage of its reactivity and structural features to create innovative solutions for industry needs.

Check Digit Verification of cas no

The CAS Registry Mumber 4897-55-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,9 and 7 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 4897-55:
(6*4)+(5*8)+(4*9)+(3*7)+(2*5)+(1*5)=136
136 % 10 = 6
So 4897-55-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H14BrN/c12-11-5-3-10(4-6-11)9-13-7-1-2-8-13/h3-6H,1-2,7-9H2

4897-55-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[(4-bromophenyl)methyl]pyrrolidine

1.2 Other means of identification

Product number -
Other names N-<4-Brom-benzyl>-pyrrolidin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4897-55-6 SDS

4897-55-6Relevant articles and documents

Zirconium-hydride-catalyzed site-selective hydroboration of amides for the synthesis of amines: Mechanism, scope, and application

Han, Bo,Jiao, Haijun,Wu, Lipeng,Zhang, Jiong

, p. 2059 - 2067 (2021/09/02)

Developing mild and efficient catalytic methods for the selective synthesis of amines is a longstanding research objective. In this respect, catalytic deoxygenative amide reduction has proven to be promising but challenging, as this approach necessitates selective C–O bond cleavage. Herein, we report the selective hydroboration of primary, secondary, and tertiary amides at room temperature catalyzed by an earth-abundant-metal catalyst, Zr-H, for accessing diverse amines. Various readily reducible functional groups, such as esters, alkynes, and alkenes, were well tolerated. Furthermore, the methodology was extended to the synthesis of bio- and drug-derived amines. Detailed mechanistic studies revealed a reaction pathway entailing aldehyde and amido complex formation via an unusual C–N bond cleavage-reformation process, followed by C–O bond cleavage.

A practical catalytic reductive amination of carboxylic acids

Andrews, Keith G.,Denton, Ross M.,Hirst, David J.,Stoll, Emma L.,Tongue, Thomas,Valette, Damien

, p. 9494 - 9500 (2020/10/02)

We report reductive alkylation reactions of amines using carboxylic acids as nominal electrophiles. The two-step reaction exploits the dual reactivity of phenylsilane and involves a silane-mediated amidation followed by a Zn(OAc)2-catalyzed amide reduction. The reaction is applicable to a wide range of amines and carboxylic acids and has been demonstrated on a large scale (305 mmol of amine). The rate differential between the reduction of tertiary and secondary amide intermediates is exemplified in a convergent synthesis of the antiretroviral medicine maraviroc. Mechanistic studies demonstrate that a residual 0.5 equivalents of carboxylic acid from the amidation step is responsible for the generation of silane reductants with augmented reactivity, which allow secondary amides, previously unreactive in zinc/phenylsilane systems, to be reduced.

Dehydrogenative Aromatization and Sulfonylation of Pyrrolidines: Orthogonal Reactivity in Photoredox Catalysis

Muralirajan, Krishnamoorthy,Kancherla, Rajesh,Rueping, Magnus

supporting information, p. 14787 - 14791 (2018/10/20)

Oxidative dehydrogenative aromatization and selective sulfonylation reactions of N-heterocycles under visible-light photoredox catalysis were established. The mild reaction conditions make this approach an appealing and versatile strategy to functionalize/oxidize pyrrolidines whereby arylsulfonyl chlorides were identified to be both catalyst regeneration and sulfonylation reagents.

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