2-(2,4-Dichloro-phenyl)-4,6-dimethyl-1-oxo-1,2-dihydro-1λ⁴-isothiazolo[5,4-b]pyridin-3-one

Base Information

• Chemical Name: 2-(2,4-Dichloro-phenyl)-4,6-dimethyl-1-oxo-1,2-dihydro-1λ⁴-isothiazolo[5,4-b]pyridin-3-one
• CAS No.: 102818-19-9
• Molecular Formula: C₁₄H₁₀Cl₂N₂O₂S
• Molecular Weight: 341.218

Synonyms:2-(2,4-Dichloro-phenyl)-4,6-dimethyl-1-oxo-1,2-dihydro-1λ⁴-isothiazolo[5,4-b]pyridin-3-one

Chemical Property of 2-(2,4-Dichloro-phenyl)-4,6-dimethyl-1-oxo-1,2-dihydro-1λ⁴-isothiazolo[5,4-b]pyridin-3-one

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(2,4-Dichloro-phenyl)-4,6-dimethyl-1-oxo-1,2-dihydro-1λ⁴-isothiazolo[5,4-b]pyridin-3-one

There total 4 articles about 2-(2,4-Dichloro-phenyl)-4,6-dimethyl-1-oxo-1,2-dihydro-1λ⁴-isothiazolo[5,4-b]pyridin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-(2,4-Dichloro-phenyl)-4,6-dimethyl-isothiazolo[5,4-b]pyridin-3-one (102818-12-2) → 2-(2,4-Dichloro-phenyl)-4,6-dimethyl-1-oxo-1,2-dihydro-1λ4-isothiazolo[5,4-b]pyridin-3-one (102818-19-9)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; 1.) -10 deg C, 2 h, 2.) room temp., overnight;

DOI:10.1055/s-1985-31365

Reference yield:

N-(2,4-dichlorophenyl)-2-cyanoacetamide (17722-32-6) → 2-(2,4-Dichloro-phenyl)-4,6-dimethyl-1-oxo-1,2-dihydro-1λ4-isothiazolo[5,4-b]pyridin-3-one (102818-19-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / H₂S, (C₂H₅)3N / pyridine

2: 83 percent / (C₂H₅)3N / ethanol / 24 h / Heating

3: 90 percent / NaOH, potassium hexacyanoferrate(III) / Ambient temperature

4: 84 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 1.) -10 deg C, 2 h, 2.) room temp., overnight

With sodium hydroxide; hydrogen sulfide; triethylamine; 3-chloro-benzenecarboperoxoic acid; potassium hexacyanoferrate(III); In pyridine; ethanol; dichloromethane;

DOI:10.1055/s-1985-31365

Reference yield:

N-(2,4-Dichloro-phenyl)-2-thiocarbamoyl-acetamide (102817-88-9) → 2-(2,4-Dichloro-phenyl)-4,6-dimethyl-1-oxo-1,2-dihydro-1λ4-isothiazolo[5,4-b]pyridin-3-one (102818-19-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / (C₂H₅)3N / ethanol / 24 h / Heating

2: 90 percent / NaOH, potassium hexacyanoferrate(III) / Ambient temperature

3: 84 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 1.) -10 deg C, 2 h, 2.) room temp., overnight

With sodium hydroxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; potassium hexacyanoferrate(III); In ethanol; dichloromethane;

DOI:10.1055/s-1985-31365

upstream raw materials:

2-(2,4-Dichloro-phenyl)-4,6-dimethyl-isothiazolo[5,4-b]pyridin-3-one

N-(2,4-dichlorophenyl)-2-cyanoacetamide

N-(2,4-Dichloro-phenyl)-2-thiocarbamoyl-acetamide

4,6-Dimethyl-2-thioxo-1,2-dihydro-pyridine-3-carboxylic acid (2,4-dichloro-phenyl)-amide

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