4-[2,5-dioxo-4-(1-hydroxypropyl)-3-methyl-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Base Information

Chemical Name:4-[2,5-dioxo-4-(1-hydroxypropyl)-3-methyl-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
CAS No.:1215085-69-0
Molecular Formula:C₂₁H₁₈F₃N₃O₃
Molecular Weight:417.387
Hs Code.:

Synonyms:4-[2,5-dioxo-4-(1-hydroxypropyl)-3-methyl-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

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Chemical Property of 4-[2,5-dioxo-4-(1-hydroxypropyl)-3-methyl-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

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Technology Process of 4-[2,5-dioxo-4-(1-hydroxypropyl)-3-methyl-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

There total 3 articles about 4-[2,5-dioxo-4-(1-hydroxypropyl)-3-methyl-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1215085-72-5
4-[2,5-dioxo-3-methyl-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

: 123-38-6
propionaldehyde

: 1215085-69-0
4-[2,5-dioxo-4-(1-hydroxypropyl)-3-methyl-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Guidance literature:: 4-[2,5-dioxo-3-methyl-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 ℃;

propionaldehyde; In tetrahydrofuran; hexane; at -78 ℃;

With ammonium chloride; In hexane; at -78 ℃;

Reference yield:

: 74641-60-4
2-methylamino-2-phenylacetic acid

: 1215085-69-0
4-[2,5-dioxo-4-(1-hydroxypropyl)-3-methyl-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 48 h / 20 °C / Inert atmosphere

2.1: 1,4-dioxane; toluene / 1.5 h / Reflux; Inert atmosphere

2.2: 17.5 h / 20 °C / Reflux; Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 0.17 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 °C / Inert atmosphere

With thionyl chloride; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; hexane; toluene;
DOI:10.1021/jm300281x

Reference yield:

: 107635-11-0
methyl α-(N-methylamino)phenylacetate

: 1215085-69-0
4-[2,5-dioxo-4-(1-hydroxypropyl)-3-methyl-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,4-dioxane; toluene / 1.5 h / Reflux; Inert atmosphere

1.2: 17.5 h / 20 °C / Reflux; Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 0.17 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

With lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; hexane; toluene;
DOI:10.1021/jm300281x