107635-11-0Relevant articles and documents
Identification of a 4-(hydroxymethyl)diarylhydantoin as a selective androgen receptor modulator
Nique, Francois,Hebbe, Severine,Triballeau, Nicolas,Peixoto, Christophe,Lefrancois, Jean-Michel,Jary, Helene,Alvey, Luke,Manioc, Murielle,Housseman, Christopher,Klaassen, Hugo,Van Beeck, Kris,Guedin, Denis,Namour, Florence,Minet, Dominque,Van Der Aar, Ellen,Feyen, Jean,Fletcher, Stephen,Blanque, Roland,Robin-Jagerschmidt, Catherine,Deprez, Pierre
supporting information, p. 8236 - 8247,12 (2020/09/15)
Structural modification performed on a 4-methyl-4-(4-hydroxyphenyl) hydantoin series is described which resulted in the development of a new series of 4-(hydroxymethyl)diarylhydantoin analogues as potent, partial agonists of the human androgen receptor. T
Sigmatropic rearrangement of ammonium ylideskey step in the synthesis of methyl 2-formylphenyl acetate
Kowalkowska, Anna,Jonczyk, Andrzej
experimental part, p. 3308 - 3317 (2011/09/21)
N-Cyanomethyl-N,N-dimethyl-N-(-methoxycarbonyl)benzylammonium salts 5 were synthesized and treated with different base/solvent systems, giving the products of sigmatropic rearrangements [2,3] 7 and [1,2] 8. In reactions carried out in liquid ammonia, [2,3] rearrangement definitively prevailed. Pure 7(or mixture of 7 and 8) were deprotected to afford methyl 2-formylphenyl acetate (9) in good yield.
NOVEL IMIDAZOLIDINE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS
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Page/Page column 43, (2010/04/06)
Novel compounds are disclosed that have a Formula represented by the following: wherein X, R1, R2a, R2b, R2c, R3a R3b, R4a, R4b, R4c, and ml are as describe
Effect of substitution on the intramolecular 1,3-dipolar cycloaddition of alkene tethered muenchnones
Belanger, Guillaume,April, Myriam,Dauphin, Etienne,Roy, Stephanie
, p. 1104 - 1111 (2007/10/03)
(Chemical Equation Presented) A sequence of chemoselective activation of N-acylaminoacids, muenchnone generation, intramolecular 1,3-dipolar cycloaddition, and ring opening efficiently generated functionalized polycyclic structures such as cyclopenta[b]py
Synthesis and utilization of a novel glycine derived chiral precursor, based on a recyclable L-prolinol auxiliary, for the enantioselective preparation of α-amino acids and their N-methyl derivatives
Pandey,Reddy,Das
, p. 3175 - 3178 (2007/10/03)
α-Amino acids and their N-methyl derivatives are synthesized in fairly high optical purity employing a new glycine derived template based on a recyclable L-prolinol chiral auxiliary.
α-lactam intermediates in base-promoted reactions of O-sulfonylated hydroxamic acids with nucleophiles
Hoffman, Robert V.,Nayyar, Naresh K.,Chen, Wenting
, p. 5031 - 5034 (2007/10/02)
The reaction of N-(sulfonyloxy) amides with bases proceeds by initial formation of an α-lactam intermediate. A primary kinetic deuterium isotope effect, kH/kD = 2.17, a leaving group effect, β1gCH3 = 0.50, and n
