1,3-DIOXO-2-PHENETHYL-2,3-DIHYDRO-1H-ISOINDOLE-5-CARBOXYLIC ACID

Base Information

• Chemical Name: 1,3-DIOXO-2-PHENETHYL-2,3-DIHYDRO-1H-ISOINDOLE-5-CARBOXYLIC ACID
• CAS No.: 166096-57-7
• Molecular Formula: C₁₇H₁₃NO₄
• Molecular Weight: 295.295
• Mol file: 166096-57-7.mol

Synonyms:1,3-dioxo-2-phenethyl-2,3-dihydro-1H-isoindole-5-carboxylic acid

Chemical Property of 1,3-DIOXO-2-PHENETHYL-2,3-DIHYDRO-1H-ISOINDOLE-5-CARBOXYLIC ACID

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

1,3-Dioxo-2-(2-phenylethyl)isoindoline-5-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

Useful:

Technology Process of 1,3-DIOXO-2-PHENETHYL-2,3-DIHYDRO-1H-ISOINDOLE-5-CARBOXYLIC ACID

There total 1 articles about 1,3-DIOXO-2-PHENETHYL-2,3-DIHYDRO-1H-ISOINDOLE-5-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenethylamine (64-04-0) + trimellitic Anhydride (552-30-7,145253-53-8) → 1,3-dioxo-2-phenethyl-2,3-dihydro-1H-isoindole-5-carboxylic acid (166096-57-7)

Guidance literature:

Heating;

DOI:10.1016/j.bmcl.2005.07.048

Reference yield:

1,3-dioxo-2-phenethyl-2,3-dihydro-1H-isoindole-5-carboxylic acid (166096-57-7) + O-(tert-butyl)hydroxylamine (37477-16-0) → 1,3-dioxo-2-phenethyl-2,3-dihydro-1H-isoindole-5-carboxylic acid tert-butoxy-amide (868622-66-6)

Guidance literature:

1,3-dioxo-2-phenethyl-2,3-dihydro-1H-isoindole-5-carboxylic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃;

O-(tert-butyl)hydroxylamine; In methanol; at 20 ℃;

DOI:10.1016/j.bmcl.2005.07.048

Reference yield:

1,3-dioxo-2-phenethyl-2,3-dihydro-1H-isoindole-5-carboxylic acid (166096-57-7) + 1,3-dimethyl-1H-pyrazol-5-ol (5203-77-0) → C22H19N3O4

Guidance literature:

1,3-dioxo-2-phenethyl-2,3-dihydro-1H-isoindole-5-carboxylic acid; With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

1,3-dimethyl-1H-pyrazol-5-ol; With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.jafc.9b04917

upstream raw materials:

phenethylamine

trimellitic Anhydride

Downstream raw materials:

1,3-dioxo-2-phenethyl-2,3-dihydro-1H-isoindole-5-carboxylic acid tert-butoxy-amide

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