(R)-8-(tert-butyldiphenylsilanyloxy)-1-((2R,4R,6R)-4-(tert-butyldiphenylsilanyloxy)-6-(2-(chloromethyl)oxazol-4-yl)tetrahydro-2H-pyran-2-yl)-4-methylene-6-(triethylsilanyloxy)octan-2-ol

Base Information

Chemical Name:(R)-8-(tert-butyldiphenylsilanyloxy)-1-((2R,4R,6R)-4-(tert-butyldiphenylsilanyloxy)-6-(2-(chloromethyl)oxazol-4-yl)tetrahydro-2H-pyran-2-yl)-4-methylene-6-(triethylsilanyloxy)octan-2-ol
CAS No.:920034-32-8
Molecular Formula:C₅₆H₇₈ClNO₆Si₃
Molecular Weight:980.948
Hs Code.:

(R)-8-(tert-butyldiphenylsilanyloxy)-1-((2R,4R,6R)-4-(tert-butyldiphenylsilanyloxy)-6-(2-(chloromethyl)oxazol-4-yl)tetrahydro-2H-pyran-2-yl)-4-methylene-6-(triethylsilanyloxy)octan-2-ol

Synonyms:(R)-8-(tert-butyldiphenylsilanyloxy)-1-((2R,4R,6R)-4-(tert-butyldiphenylsilanyloxy)-6-(2-(chloromethyl)oxazol-4-yl)tetrahydro-2H-pyran-2-yl)-4-methylene-6-(triethylsilanyloxy)octan-2-ol

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Chemical Property of (R)-8-(tert-butyldiphenylsilanyloxy)-1-((2R,4R,6R)-4-(tert-butyldiphenylsilanyloxy)-6-(2-(chloromethyl)oxazol-4-yl)tetrahydro-2H-pyran-2-yl)-4-methylene-6-(triethylsilanyloxy)octan-2-ol

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Technology Process of (R)-8-(tert-butyldiphenylsilanyloxy)-1-((2R,4R,6R)-4-(tert-butyldiphenylsilanyloxy)-6-(2-(chloromethyl)oxazol-4-yl)tetrahydro-2H-pyran-2-yl)-4-methylene-6-(triethylsilanyloxy)octan-2-ol

There total 21 articles about (R)-8-(tert-butyldiphenylsilanyloxy)-1-((2R,4R,6R)-4-(tert-butyldiphenylsilanyloxy)-6-(2-(chloromethyl)oxazol-4-yl)tetrahydro-2H-pyran-2-yl)-4-methylene-6-(triethylsilanyloxy)octan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 2-((2S,4R,6R)-4-(tert-butyldiphenylsilanyloxy)-6-(2-(chloromethyl)oxazol-4-yl)tetrahydro-2H-pyran-2-yl)acetaldehyde

: C₃₁H₅₂O₂Si₃

: (2R,6R)-8-(tert-butyldiphenylsilyloxy)-1-((2R,4R,6R)-4-(tert-butyldiphenylsilyloxy)-6-(2-(chloromethyl)oxazol-4-yl)-tetrahydro-2H-pyran-2-yl)-4-methylene-6-(triethylsilyloxy)octan-2-ol

: 920034-32-8
(R)-8-(tert-butyldiphenylsilanyloxy)-1-((2R,4R,6R)-4-(tert-butyldiphenylsilanyloxy)-6-(2-(chloromethyl)oxazol-4-yl)tetrahydro-2H-pyran-2-yl)-4-methylene-6-(triethylsilanyloxy)octan-2-ol

Guidance literature:: C₃₁H₅₂O₂Si₃; With tin(IV) chloride; In dichloromethane; at -78 ℃; for 0.5h;

2-((2S,4R,6R)-4-(tert-butyldiphenylsilanyloxy)-6-(2-(chloromethyl)oxazol-4-yl)tetrahydro-2H-pyran-2-yl)acetaldehyde; In dichloromethane; at -78 ℃; for 1h;
DOI:10.1021/ol062531j

Reference yield: 63.0%

: 2-((2S,4R,6R)-4-(tert-butyldiphenylsilanyloxy)-6-(2-(chloromethyl)oxazol-4-yl)tetrahydro-2H-pyran-2-yl)acetaldehyde

: (R)-9,9-diethyl-2,2-dimethyl-3,3-diphenyl-7-(2-((trimethylsilyl)methyl)allyl)-4,8-dioxa-3,9-disilaundecane

: (2R,6R)-8-(tert-butyldiphenylsilyloxy)-1-((2R,4R,6R)-4-(tert-butyldiphenylsilyloxy)-6-(2-(chloromethyl)oxazol-4-yl)-tetrahydro-2H-pyran-2-yl)-4-methylene-6-(triethylsilyloxy)octan-2-ol

: 920034-32-8
(R)-8-(tert-butyldiphenylsilanyloxy)-1-((2R,4R,6R)-4-(tert-butyldiphenylsilanyloxy)-6-(2-(chloromethyl)oxazol-4-yl)tetrahydro-2H-pyran-2-yl)-4-methylene-6-(triethylsilanyloxy)octan-2-ol

Guidance literature:: (R)-9,9-diethyl-2,2-dimethyl-3,3-diphenyl-7-(2-((trimethylsilyl)methyl)allyl)-4,8-dioxa-3,9-disilaundecane; In dichloromethane; at -78 ℃; for 0.5h;

2-((2S,4R,6R)-4-(tert-butyldiphenylsilanyloxy)-6-(2-(chloromethyl)oxazol-4-yl)tetrahydro-2H-pyran-2-yl)acetaldehyde; In dichloromethane; at -78 ℃; for 1h;
DOI:10.1039/c2ob25766a

Reference yield:

: [4-(tert-butyl-diphenyl-silanyloxy)-6-(2-chloromethyl-oxazol-4-yl)-tetrahydro-pyran-2-yl]-acetic acid ethyl ester

: 920034-32-8
(R)-8-(tert-butyldiphenylsilanyloxy)-1-((2R,4R,6R)-4-(tert-butyldiphenylsilanyloxy)-6-(2-(chloromethyl)oxazol-4-yl)tetrahydro-2H-pyran-2-yl)-4-methylene-6-(triethylsilanyloxy)octan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 92 percent / diisobutylaluminium hydride / CH₂Cl₂ / 3 h / -78 °C

2.1: tin tetrachloride / CH₂Cl₂ / 0.5 h / -78 °C

2.2: 63 percent / CH₂Cl₂ / 1 h / -78 °C

With tin(IV) chloride; diisobutylaluminium hydride; In dichloromethane;
DOI:10.1021/ol062531j