3-[2-(3,5-bis-trifluoromethyl-benzyloxymethyl)-[1,3]dithiolan-2-yl]-3-(3,4-dichloro-phenyl)-propan-1-ol

Base Information

• Chemical Name: 3-[2-(3,5-bis-trifluoromethyl-benzyloxymethyl)-[1,3]dithiolan-2-yl]-3-(3,4-dichloro-phenyl)-propan-1-ol
• CAS No.: 315718-17-3
• Molecular Formula: C₂₂H₂₀Cl₂F₆O₂S₂
• Molecular Weight: 565.428
• Mol file: 315718-17-3.mol

Synonyms:3-[2-(3,5-bis-trifluoromethyl-benzyloxymethyl)-[1,3]dithiolan-2-yl]-3-(3,4-dichloro-phenyl)-propan-1-ol

Chemical Property of 3-[2-(3,5-bis-trifluoromethyl-benzyloxymethyl)-[1,3]dithiolan-2-yl]-3-(3,4-dichloro-phenyl)-propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[2-(3,5-bis-trifluoromethyl-benzyloxymethyl)-[1,3]dithiolan-2-yl]-3-(3,4-dichloro-phenyl)-propan-1-ol

There total 5 articles about 3-[2-(3,5-bis-trifluoromethyl-benzyloxymethyl)-[1,3]dithiolan-2-yl]-3-(3,4-dichloro-phenyl)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

[3-[2-(3,5-bis-trifluoromethyl-benzyloxymethyl)-[1,3]dithiolan-2-yl]-3-(3,4-dichloro-phenyl)-propoxy]-tert-butyl-dimethyl-silane (184969-90-2) → 3-[2-(3,5-bis-trifluoromethyl-benzyloxymethyl)-[1,3]dithiolan-2-yl]-3-(3,4-dichloro-phenyl)-propan-1-ol (315718-17-3)

Guidance literature:

With hydrogen fluoride; In acetonitrile;

DOI:10.1016/S0960-894X(00)00464-9

Reference yield:

methyl 3-(3,4-dichlorophenyl)-2-propenoate (82475-75-0) → 3-[2-(3,5-bis-trifluoromethyl-benzyloxymethyl)-[1,3]dithiolan-2-yl]-3-(3,4-dichloro-phenyl)-propan-1-ol (315718-17-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 87 percent / LiN(TMS)2 / tetrahydrofuran / -78 °C

2: 92 percent / LiAlH₄ / tetrahydrofuran / 0 - 23 °C

3: 96 percent / Et₃N; DMAP / tetrahydrofuran / 0 - 23 °C

4: 88 percent / KN(TMS)2 / tetrahydrofuran / 0 - 23 °C

5: 100 percent / HF / acetonitrile

With dmap; lithium aluminium tetrahydride; hydrogen fluoride; potassium hexamethylsilazane; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; acetonitrile; 1: Addition / 2: Reduction / 3: silylation / 4: Alkylation / 5: desilylation;

DOI:10.1016/S0960-894X(00)00464-9

Reference yield:

3-(3,4-dichloro-phenyl)-3-(2-hydroxymethyl-[1,3]dithiolan-2-yl)-propan-1-ol (184969-87-7) → 3-[2-(3,5-bis-trifluoromethyl-benzyloxymethyl)-[1,3]dithiolan-2-yl]-3-(3,4-dichloro-phenyl)-propan-1-ol (315718-17-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / Et₃N; DMAP / tetrahydrofuran / 0 - 23 °C

2: 88 percent / KN(TMS)2 / tetrahydrofuran / 0 - 23 °C

3: 100 percent / HF / acetonitrile

With dmap; hydrogen fluoride; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; acetonitrile; 1: silylation / 2: Alkylation / 3: desilylation;

DOI:10.1016/S0960-894X(00)00464-9

upstream raw materials:

[3-[2-(3,5-bis-trifluoromethyl-benzyloxymethyl)-[1,3]dithiolan-2-yl]-3-(3,4-dichloro-phenyl)-propoxy]-tert-butyl-dimethyl-silane

methyl 3-(3,4-dichlorophenyl)-2-propenoate

3-(3,4-dichloro-phenyl)-3-(2-hydroxymethyl-[1,3]dithiolan-2-yl)-propan-1-ol

2-[1-(3,4-dichloro-phenyl)-2-methoxycarbonyl-ethyl]-[1,3]dithiolane-2-carboxylic acid ethyl ester