1-[[3,5-Bis(trifluoromethyl)phenyl]methoxy]-3-(3,4-dichloro-phenyl)-5-hydroxy-2-pentanone

Base Information

Chemical Name:1-[[3,5-Bis(trifluoromethyl)phenyl]methoxy]-3-(3,4-dichloro-phenyl)-5-hydroxy-2-pentanone
CAS No.:184969-91-3
Molecular Formula:C₂₀H₁₆Cl₂F₆O₃
Molecular Weight:489.242
Hs Code.:

Synonyms:1-[[3,5-Bis(trifluoromethyl)phenyl]methoxy]-3-(3,4-dichloro-phenyl)-5-hydroxy-2-pentanone

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Chemical Property of 1-[[3,5-Bis(trifluoromethyl)phenyl]methoxy]-3-(3,4-dichloro-phenyl)-5-hydroxy-2-pentanone

Chemical Property:

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Technology Process of 1-[[3,5-Bis(trifluoromethyl)phenyl]methoxy]-3-(3,4-dichloro-phenyl)-5-hydroxy-2-pentanone

There total 7 articles about 1-[[3,5-Bis(trifluoromethyl)phenyl]methoxy]-3-(3,4-dichloro-phenyl)-5-hydroxy-2-pentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 315718-17-3
3-[2-(3,5-bis-trifluoromethyl-benzyloxymethyl)-[1,3]dithiolan-2-yl]-3-(3,4-dichloro-phenyl)-propan-1-ol

: 184969-91-3
1-[[3,5-Bis(trifluoromethyl)phenyl]methoxy]-3-(3,4-dichloro-phenyl)-5-hydroxy-2-pentanone

Guidance literature:: With mercury(II) perchlorate; calcium carbonate; In tetrahydrofuran;
DOI:10.1016/S0960-894X(00)00464-9

Reference yield:

: 82475-75-0
methyl 3-(3,4-dichlorophenyl)-2-propenoate

: 184969-91-3
1-[[3,5-Bis(trifluoromethyl)phenyl]methoxy]-3-(3,4-dichloro-phenyl)-5-hydroxy-2-pentanone

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / LiN(TMS)2 / tetrahydrofuran / -78 °C

2: 92 percent / LiAlH₄ / tetrahydrofuran / 0 - 23 °C

3: 96 percent / Et₃N; DMAP / tetrahydrofuran / 0 - 23 °C

4: 88 percent / KN(TMS)2 / tetrahydrofuran / 0 - 23 °C

5: 100 percent / HF / acetonitrile

6: 100 percent / Hg(ClO₄)2; aq. CaCO₃ / tetrahydrofuran

With dmap; lithium aluminium tetrahydride; mercury(II) perchlorate; hydrogen fluoride; potassium hexamethylsilazane; triethylamine; calcium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; acetonitrile; 1: Addition / 2: Reduction / 3: silylation / 4: Alkylation / 5: desilylation / 6: Hydrolysis;
DOI:10.1016/S0960-894X(00)00464-9

Reference yield:

: 184969-87-7
3-(3,4-dichloro-phenyl)-3-(2-hydroxymethyl-[1,3]dithiolan-2-yl)-propan-1-ol

: 184969-91-3
1-[[3,5-Bis(trifluoromethyl)phenyl]methoxy]-3-(3,4-dichloro-phenyl)-5-hydroxy-2-pentanone

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / Et₃N; DMAP / tetrahydrofuran / 0 - 23 °C

2: 88 percent / KN(TMS)2 / tetrahydrofuran / 0 - 23 °C

3: 100 percent / HF / acetonitrile

4: 100 percent / Hg(ClO₄)2; aq. CaCO₃ / tetrahydrofuran

With dmap; mercury(II) perchlorate; hydrogen fluoride; potassium hexamethylsilazane; triethylamine; calcium carbonate; In tetrahydrofuran; acetonitrile; 1: silylation / 2: Alkylation / 3: desilylation / 4: Hydrolysis;
DOI:10.1016/S0960-894X(00)00464-9