1-[2,6-Dimethoxy-4-((Z)-2-nitro-propenyl)-phenyl]-4,5-dimethoxy-naphthalene-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 1-[2,6-Dimethoxy-4-((Z)-2-nitro-propenyl)-phenyl]-4,5-dimethoxy-naphthalene-2-carboxylic acid methyl ester
• CAS No.: 123796-64-5
• Molecular Formula: C₂₅H₂₅NO₈
• Molecular Weight: 467.475
• Mol file: 123796-64-5.mol

Synonyms:1-[2,6-Dimethoxy-4-((Z)-2-nitro-propenyl)-phenyl]-4,5-dimethoxy-naphthalene-2-carboxylic acid methyl ester

Chemical Property of 1-[2,6-Dimethoxy-4-((Z)-2-nitro-propenyl)-phenyl]-4,5-dimethoxy-naphthalene-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2,6-Dimethoxy-4-((Z)-2-nitro-propenyl)-phenyl]-4,5-dimethoxy-naphthalene-2-carboxylic acid methyl ester

There total 1 articles about 1-[2,6-Dimethoxy-4-((Z)-2-nitro-propenyl)-phenyl]-4,5-dimethoxy-naphthalene-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Nitroethane (79-24-3) + Methyl 1-(4-Formyl-2,6-dimethoxyphenyl)-4,5-dimethoxynaphthalene-2-carboxylate (123796-63-4) → 1-[2,6-Dimethoxy-4-((Z)-2-nitro-propenyl)-phenyl]-4,5-dimethoxy-naphthalene-2-carboxylic acid methyl ester (123796-64-5)

Guidance literature:

With ammonium acetate; In acetic acid; at 80 ℃; for 1.5h;

DOI:10.1039/c39890000301

Reference yield: 82.0%

1-[2,6-Dimethoxy-4-((Z)-2-nitro-propenyl)-phenyl]-4,5-dimethoxy-naphthalene-2-carboxylic acid methyl ester (123796-64-5) → 1-<4-(2-Aminopropyl)-2,6-dimethoxyphenyl>-4,5-dimethoxy-2-naphthylmethanol (123796-65-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2.5h; Heating;

DOI:10.1039/c39890000301

Reference yield:

1-[2,6-Dimethoxy-4-((Z)-2-nitro-propenyl)-phenyl]-4,5-dimethoxy-naphthalene-2-carboxylic acid methyl ester (123796-64-5) → N-<2-<4-(4,5-Dimethoxy-2-methyl-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>acetamide (123796-68-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / LiAlH₄ / tetrahydrofuran / 2.5 h / Heating

2: 87 percent / pyridine / 2.5 h / 35 - 40 °C

3: 81 percent / NaOMe / methanol / 1.5 h / 25 °C

4: 1.) Me₃SiCl, NaI; 2.) Zn/AcOH / 1.) MeCN, degC, 1h; 2.) 80 degC, 4.5 h

With lithium aluminium tetrahydride; chloro-trimethyl-silane; sodium methylate; acetic acid; sodium iodide; zinc; In tetrahydrofuran; pyridine; methanol;

DOI:10.1039/c39890000301

upstream raw materials:

Nitroethane

Methyl 1-(4-Formyl-2,6-dimethoxyphenyl)-4,5-dimethoxynaphthalene-2-carboxylate

Downstream raw materials:

1-<4-(2-Aminopropyl)-2,6-dimethoxyphenyl>-4,5-dimethoxy-2-naphthylmethanol

ancistrocladisine

N-<2-<4-(4,5-Dimethoxy-2-methyl-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>acetamide

N-<2-<2-(Hydroxymethyl-4,5-dimethoxy-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>acetamide