Methyl 1-(4-Formyl-2,6-dimethoxyphenyl)-4,5-dimethoxynaphthalene-2-carboxylate

Base Information

• Chemical Name: Methyl 1-(4-Formyl-2,6-dimethoxyphenyl)-4,5-dimethoxynaphthalene-2-carboxylate
• CAS No.: 123796-63-4
• Molecular Formula: C₂₃H₂₂O₇
• Molecular Weight: 410.423
• Mol file: 123796-63-4.mol

Synonyms:Methyl 1-(4-Formyl-2,6-dimethoxyphenyl)-4,5-dimethoxynaphthalene-2-carboxylate

Chemical Property of Methyl 1-(4-Formyl-2,6-dimethoxyphenyl)-4,5-dimethoxynaphthalene-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 1-(4-Formyl-2,6-dimethoxyphenyl)-4,5-dimethoxynaphthalene-2-carboxylate

There total 10 articles about Methyl 1-(4-Formyl-2,6-dimethoxyphenyl)-4,5-dimethoxynaphthalene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(4-Formyl-2,6-dimethoxy-phenyl)-4,5-dimethoxy-naphthalene-2-carboxylic acid + methyl iodide (74-88-4) → Methyl 1-(4-Formyl-2,6-dimethoxyphenyl)-4,5-dimethoxynaphthalene-2-carboxylate (123796-63-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 16h; Ambient temperature;

DOI:10.1039/P19910000841

Reference yield:

4-bromo-3,5-dimethoxybenzaldehyde (31558-40-4) → Methyl 1-(4-Formyl-2,6-dimethoxyphenyl)-4,5-dimethoxynaphthalene-2-carboxylate (123796-63-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / toluene-p-sulphonic acid / benzene / 20 h / Heating

2: 1.) Mg / 1.) THF, 2a.) 16h, r.t., 2b.) reflux, 2h

4: 90 percent / anhydrous potassium carbonate / dimethylformamide / 16 h / Ambient temperature

With potassium carbonate; toluene-4-sulfonic acid; magnesium; In N,N-dimethyl-formamide; benzene;

DOI:10.1039/P19910000841

Reference yield:

5-acetoxy-2-bromo-1,4-naphthoquinone (77189-69-6) → Methyl 1-(4-Formyl-2,6-dimethoxyphenyl)-4,5-dimethoxynaphthalene-2-carboxylate (123796-63-4)

Guidance literature:

Multi-step reaction with 8 steps

1: 1.) Na₂S₂O₄, 2.) tetrabutylammonium bromide, NaOH / 1.) ether, CH₂Cl₂, water, 10 min, 2.) r.t., 15h

2: 88 percent / dimethylformamide / 16 h / Heating

3: 84 percent / potassium hydroxide / methanol; H₂O / 72 h / Heating

4: oxalyl chloride / CH₂Cl₂ / 2.5 h / Ambient temperature

5: thionyl chloride / 1.) dichloromethane, r.t., 2h, 2.) r.t., 1.5h

6: 1.) Mg / 1.) THF, 2a.) 16h, r.t., 2b.) reflux, 2h

8: 90 percent / anhydrous potassium carbonate / dimethylformamide / 16 h / Ambient temperature

With potassium hydroxide; sodium hydroxide; thionyl chloride; sodium dithionite; oxalyl dichloride; tetrabutylammomium bromide; potassium carbonate; magnesium; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1039/P19910000841

upstream raw materials:

methyl iodide

4-bromo-3,5-dimethoxybenzaldehyde

5-acetoxy-2-bromo-1,4-naphthoquinone

1,4,5-Trimethoxynaphthalene-2-carbonitrile

Downstream raw materials:

Acetic acid 1-[4-(2-acetylamino-propyl)-2,6-dimethoxy-phenyl]-4,5-dimethoxy-naphthalen-2-ylmethyl ester

N-<2-<2-(Hydroxymethyl-4,5-dimethoxy-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>acetamide

N-<2-<4-(4,5-Dimethoxy-2-methyl-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>acetamide

1-<4-(2-Aminopropyl)-2,6-dimethoxyphenyl>-4,5-dimethoxy-2-naphthylmethanol