(1S)-2,3,5,6-tetra-O-benzyl-1,4-dideoxy-1-C-{(2S)-3-[(ethyl)(2',3'-O-isopropylideneuridin-5'-yl)phosphoryl]-2-hydroxypropyl}-1,4-imino-D-galactitol

Base Information

Chemical Name:(1S)-2,3,5,6-tetra-O-benzyl-1,4-dideoxy-1-C-{(2S)-3-[(ethyl)(2',3'-O-isopropylideneuridin-5'-yl)phosphoryl]-2-hydroxypropyl}-1,4-imino-D-galactitol
CAS No.:912955-05-6
Molecular Formula:C₅₁H₆₂N₃O₁₃P
Molecular Weight:956.039
Hs Code.:

Synonyms:(1S)-2,3,5,6-tetra-O-benzyl-1,4-dideoxy-1-C-{(2S)-3-[(ethyl)(2',3'-O-isopropylideneuridin-5'-yl)phosphoryl]-2-hydroxypropyl}-1,4-imino-D-galactitol

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Chemical Property of (1S)-2,3,5,6-tetra-O-benzyl-1,4-dideoxy-1-C-{(2S)-3-[(ethyl)(2',3'-O-isopropylideneuridin-5'-yl)phosphoryl]-2-hydroxypropyl}-1,4-imino-D-galactitol

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Technology Process of (1S)-2,3,5,6-tetra-O-benzyl-1,4-dideoxy-1-C-{(2S)-3-[(ethyl)(2',3'-O-isopropylideneuridin-5'-yl)phosphoryl]-2-hydroxypropyl}-1,4-imino-D-galactitol

There total 6 articles about (1S)-2,3,5,6-tetra-O-benzyl-1,4-dideoxy-1-C-{(2S)-3-[(ethyl)(2',3'-O-isopropylideneuridin-5'-yl)phosphoryl]-2-hydroxypropyl}-1,4-imino-D-galactitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 912955-04-5
ethyl (2',3'-O-isopropylideneuridin-5'-yl)(2S,3aS,4S,5S,6S)-4,5-dibenzyloxy-6-[(1S)-1,2-dibenzyloxyethyl]hexahydropyrrolo[1,2-b]isoxazole-2-methylphosphonate

: 912955-05-6
(1S)-2,3,5,6-tetra-O-benzyl-1,4-dideoxy-1-C-{(2S)-3-[(ethyl)(2',3'-O-isopropylideneuridin-5'-yl)phosphoryl]-2-hydroxypropyl}-1,4-imino-D-galactitol

Guidance literature:: With copper diacetate; acetic acid; zinc; In water; at 70 ℃; for 1h;
DOI:10.1021/jo061130e

Reference yield:

: 912955-03-4
ethyl (2',3'-O-isopropylideneuridin-5'-yl) allylphosphonate

: 912955-05-6
(1S)-2,3,5,6-tetra-O-benzyl-1,4-dideoxy-1-C-{(2S)-3-[(ethyl)(2',3'-O-isopropylideneuridin-5'-yl)phosphoryl]-2-hydroxypropyl}-1,4-imino-D-galactitol

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / tetrachloroethene / 36 h / 60 - 70 °C

2: 68 percent / Zn; Cu(OAc)2; AcOH / H₂O / 1 h / 70 °C

With copper diacetate; acetic acid; zinc; In 1,1,2,2-tetrachloroethylene; water;
DOI:10.1021/jo061130e

Reference yield:

: 912954-96-2
(2S,3S,4S)-3,4-bis(benzyloxy)-2-((S)-1,2-bis(benzyloxy)ethyl)-3,4-dihydro-2H-pyrrole-1-oxide

: 912955-05-6
(1S)-2,3,5,6-tetra-O-benzyl-1,4-dideoxy-1-C-{(2S)-3-[(ethyl)(2',3'-O-isopropylideneuridin-5'-yl)phosphoryl]-2-hydroxypropyl}-1,4-imino-D-galactitol

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / tetrachloroethene / 36 h / 60 - 70 °C

2: 68 percent / Zn; Cu(OAc)2; AcOH / H₂O / 1 h / 70 °C

With copper diacetate; acetic acid; zinc; In 1,1,2,2-tetrachloroethylene; water;
DOI:10.1021/jo061130e