(2R)-tert-butyl 4-fluoro-2-(3-fluorophenyl)pyrrolidine-1-carboxylate-4-d

Base Information

Chemical Name:(2R)-tert-butyl 4-fluoro-2-(3-fluorophenyl)pyrrolidine-1-carboxylate-4-d
CAS No.:1364890-05-0
Molecular Formula:C₁₅H₁₉F₂NO₂
Molecular Weight:284.31
Hs Code.:

Synonyms:(2R)-tert-butyl 4-fluoro-2-(3-fluorophenyl)pyrrolidine-1-carboxylate-4-d

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Chemical Property of (2R)-tert-butyl 4-fluoro-2-(3-fluorophenyl)pyrrolidine-1-carboxylate-4-d

Chemical Property:

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Technology Process of (2R)-tert-butyl 4-fluoro-2-(3-fluorophenyl)pyrrolidine-1-carboxylate-4-d

There total 6 articles about (2R)-tert-butyl 4-fluoro-2-(3-fluorophenyl)pyrrolidine-1-carboxylate-4-d which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1364890-04-9
(2R)-tert-butyl 2-(3-fluorophenyl)-4-hydroxypyrrolidine-1-carboxylate-4-d

: 1364890-05-0
(2R)-tert-butyl 4-fluoro-2-(3-fluorophenyl)pyrrolidine-1-carboxylate-4-d

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at -78 - 20 ℃; for 1h; Plastic bottle;

Reference yield:

: 1223404-92-9
(2R,4R)-tert-butyl 2-(3-fluorophenyl)-4-hydroxypyrrolidine-1-carboxylate

: 1364890-05-0
(2R)-tert-butyl 4-fluoro-2-(3-fluorophenyl)pyrrolidine-1-carboxylate-4-d

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichloroisocyanuric acid / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 1.25 h / -10 - 20 °C

2.1: sodium borodeuteride / tetrahydrofuran / 12 h

2.2: 0.5 h

3.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / -78 - 20 °C / Plastic bottle

With sodium borodeuteride; diethylamino-sulfur trifluoride; trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1364889-99-5
(4R)-tert-butyl 4-(tert-butyldimethylsilyloxy)-2-(3-fluorophenyl)pyrrolidine-1-carboxylate

: 1364890-05-0
(2R)-tert-butyl 4-fluoro-2-(3-fluorophenyl)pyrrolidine-1-carboxylate-4-d

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

1.2: 20 °C

2.1: trichloroisocyanuric acid / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 1.25 h / -10 - 20 °C

3.1: sodium borodeuteride / tetrahydrofuran / 12 h

3.2: 0.5 h

4.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / -78 - 20 °C / Plastic bottle

With sodium borodeuteride; diethylamino-sulfur trifluoride; trichloroisocyanuric acid; tetrabutyl ammonium fluoride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In tetrahydrofuran; dichloromethane;