tert-butyl (2R)-2-(tert-butyldimethylsilyloxy)-4-(3-fluorophenyl)-4-hydroxybutylcarbamate

Base Information

Chemical Name:tert-butyl (2R)-2-(tert-butyldimethylsilyloxy)-4-(3-fluorophenyl)-4-hydroxybutylcarbamate
CAS No.:1364889-98-4
Molecular Formula:C₂₁H₃₆FNO₄Si
Molecular Weight:413.605
Hs Code.:

Synonyms:tert-butyl (2R)-2-(tert-butyldimethylsilyloxy)-4-(3-fluorophenyl)-4-hydroxybutylcarbamate

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Chemical Property of tert-butyl (2R)-2-(tert-butyldimethylsilyloxy)-4-(3-fluorophenyl)-4-hydroxybutylcarbamate

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Technology Process of tert-butyl (2R)-2-(tert-butyldimethylsilyloxy)-4-(3-fluorophenyl)-4-hydroxybutylcarbamate

There total 3 articles about tert-butyl (2R)-2-(tert-butyldimethylsilyloxy)-4-(3-fluorophenyl)-4-hydroxybutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17318-03-5
bromo(3-fluorophenyl)magnesium

: 228267-20-7
tert-butyl (R)-4-((tert-butyldimethylsilyl)oxy)-2-oxopyrrolidine-1-carboxylate

: 1364889-98-4
tert-butyl (2R)-2-(tert-butyldimethylsilyloxy)-4-(3-fluorophenyl)-4-hydroxybutylcarbamate

Guidance literature:: bromo(3-fluorophenyl)magnesium; tert-butyl (R)-4-((tert-butyldimethylsilyl)oxy)-2-oxopyrrolidine-1-carboxylate; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

With methanol; sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1364889-98-4
tert-butyl (2R)-2-(tert-butyldimethylsilyloxy)-4-(3-fluorophenyl)-4-hydroxybutylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

2.1: dmap; triethylamine / acetonitrile / 0 - 20 °C / Inert atmosphere

3.1: tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3.2: 1 h / 0 °C

With 1H-imidazole; dmap; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 131653-51-5
(4R)-4-((tert-butyl(dimethyl)silyl)oxy)pyrrolidin-2-one

: 1364889-98-4
tert-butyl (2R)-2-(tert-butyldimethylsilyloxy)-4-(3-fluorophenyl)-4-hydroxybutylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; triethylamine / acetonitrile / 0 - 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2.2: 1 h / 0 °C

With dmap; triethylamine; In tetrahydrofuran; acetonitrile;