6β,19-epoxy-17β-hydroxy-androst-4-en-3-one 17-benzoate

Base Information

• Chemical Name: 6β,19-epoxy-17β-hydroxy-androst-4-en-3-one 17-benzoate
• CAS No.: 20155-04-8
• Molecular Formula: C₂₆H₃₀O₄
• Molecular Weight: 406.522
• Mol file: 20155-04-8.mol

Synonyms:6β,19-epoxy-17β-hydroxy-androst-4-en-3-one 17-benzoate

Chemical Property of 6β,19-epoxy-17β-hydroxy-androst-4-en-3-one 17-benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6β,19-epoxy-17β-hydroxy-androst-4-en-3-one 17-benzoate

There total 5 articles about 6β,19-epoxy-17β-hydroxy-androst-4-en-3-one 17-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-6β,19-epoxy-17β-hydroxy-5α-androstan-3-one benzoate (20155-03-7) → 6β,19-epoxy-17β-hydroxy-androst-4-en-3-one 17-benzoate (20155-04-8)

Guidance literature:

With sodium hydrogencarbonate; In pyridine; water; at 100 ℃; for 3h;

DOI:10.1135/cccc19822423

Reference yield:

5-bromo-6β,19-epoxy-5α-androstane-3β,17β-diol 17-benzoate (20155-01-5) → 6β,19-epoxy-17β-hydroxy-androst-4-en-3-one 17-benzoate (20155-04-8)

Guidance literature:

With chromium trioxide-pyridine complex; for 6h; Ambient temperature;

DOI:10.1135/cccc19822423

Reference yield:

5-bromo-6β,19-epoxy-5α-androstane-3β,17β-diol 3-acetate 17-benzoate (20154-99-8) → 6β,19-epoxy-17β-hydroxy-androst-4-en-3-one 17-benzoate (20155-04-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 18.1 g / KOH / methanol; tetrahydrofuran / 1.5 h / 16 °C

2: 12 g / CrO₃-pyridine / 6 h / Ambient temperature

With potassium hydroxide; chromium trioxide-pyridine complex; In tetrahydrofuran; methanol;

DOI:10.1135/cccc19822423

upstream raw materials:

5-bromo-6β,19-epoxy-5α-androstane-3β,17β-diol 17-benzoate

5-bromo-6β,19-epoxy-17β-hydroxy-5α-androstan-3-one benzoate

5-bromo-6β,19-oxido-3β-hydroxy-5α-androstan-17-one 3-acetate

5-bromo-6β,19-epoxy-5α-androstane-3β,17β-diol 3-acetate 17-benzoate

Downstream raw materials:

6β,19-epoxy-17β-hydroxy-androst-4-en-3-one

17β,19-dihydroxy-androst-4-en-3-one 17-benzoate 19-acetate

17β,19-dihydroxy-androst-4-en-3-one 17-benzoate

Refernces