17β,19-dihydroxy-androst-4-en-3-one 17-benzoate 19-acetate

Base Information

• Chemical Name: 17β,19-dihydroxy-androst-4-en-3-one 17-benzoate 19-acetate
• CAS No.: 84600-26-0
• Molecular Formula: C₂₈H₃₄O₅
• Molecular Weight: 450.575
• Mol file: 84600-26-0.mol

Synonyms:17β,19-dihydroxy-androst-4-en-3-one 17-benzoate 19-acetate

Chemical Property of 17β,19-dihydroxy-androst-4-en-3-one 17-benzoate 19-acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 17β,19-dihydroxy-androst-4-en-3-one 17-benzoate 19-acetate

There total 6 articles about 17β,19-dihydroxy-androst-4-en-3-one 17-benzoate 19-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6β,19-epoxy-17β-hydroxy-androst-4-en-3-one 17-benzoate (20155-04-8) → 17β,19-dihydroxy-androst-4-en-3-one 17-benzoate 19-acetate (84600-26-0) + 17β,19-dihydroxy-androst-4-en-3-one 17-benzoate (20155-05-9)

Guidance literature:

With zinc; In acetic acid; at 100 ℃; for 0.666667h;

DOI:10.1135/cccc19822423

Reference yield:

5-bromo-6β,19-epoxy-5α-androstane-3β,17β-diol 3-acetate 17-benzoate (20154-99-8) → 17β,19-dihydroxy-androst-4-en-3-one 17-benzoate 19-acetate (84600-26-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 18.1 g / KOH / methanol; tetrahydrofuran / 1.5 h / 16 °C

2: 12 g / CrO₃-pyridine / 6 h / Ambient temperature

3: 2.5 g / Zn / acetic acid / 0.67 h / 100 °C

With potassium hydroxide; chromium trioxide-pyridine complex; zinc; In tetrahydrofuran; methanol; acetic acid;

DOI:10.1135/cccc19822423

Reference yield:

5-bromo-6β,19-oxido-3β-hydroxy-5α-androstan-17-one 3-acetate (2685-64-5) → 17β,19-dihydroxy-androst-4-en-3-one 17-benzoate 19-acetate (84600-26-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.8 g / lithium tri-tert-butoxyaluminium hydride / tetrahydrofuran / 0.67 h / Ambient temperature

2: 1.8 g / pyridine / 24 h / Ambient temperature

3: 18.1 g / KOH / methanol; tetrahydrofuran / 1.5 h / 16 °C

4: 12 g / CrO₃-pyridine / 6 h / Ambient temperature

5: 2.5 g / Zn / acetic acid / 0.67 h / 100 °C

With pyridine; potassium hydroxide; lithium tri(t-butoxy)aluminum hydride; chromium trioxide-pyridine complex; zinc; In tetrahydrofuran; methanol; acetic acid;

DOI:10.1135/cccc19822423

upstream raw materials:

6β,19-epoxy-17β-hydroxy-androst-4-en-3-one 17-benzoate

5-bromo-6β,19-oxido-3β-hydroxy-5α-androstan-17-one 3-acetate

5-bromo-6β,19-epoxy-5α-androstane-3β,17β-diol 3-acetate 17-benzoate

5-bromo-6β,19-epoxy-5α-androstane-3β,17β-diol 3-acetate

Refernces