2-Chloro-13a-(2-fluorophenyl)-12,13a-dihydro-6-methyl-9H,11H-imidazo[1,5-a]oxazolo[3,2-d][1,4]benzodiazepine

Base Information

Chemical Name:2-Chloro-13a-(2-fluorophenyl)-12,13a-dihydro-6-methyl-9H,11H-imidazo[1,5-a]oxazolo[3,2-d][1,4]benzodiazepine
CAS No.:59469-38-4
Molecular Formula:C₂₀H₁₇ClFN₃O
Molecular Weight:369.826
Hs Code.:

Synonyms:2-Chloro-13a-(2-fluorophenyl)-12,13a-dihydro-6-methyl-9H,11H-imidazo[1,5-a]oxazolo[3,2-d][1,4]benzodiazepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Chloro-13a-(2-fluorophenyl)-12,13a-dihydro-6-methyl-9H,11H-imidazo[1,5-a]oxazolo[3,2-d][1,4]benzodiazepine

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Technology Process of 2-Chloro-13a-(2-fluorophenyl)-12,13a-dihydro-6-methyl-9H,11H-imidazo[1,5-a]oxazolo[3,2-d][1,4]benzodiazepine

There total 10 articles about 2-Chloro-13a-(2-fluorophenyl)-12,13a-dihydro-6-methyl-9H,11H-imidazo[1,5-a]oxazolo[3,2-d][1,4]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-21-8,99932-75-9
oxirane

: 59467-70-8
Midazolam

: 59469-38-4
2-Chloro-13a-(2-fluorophenyl)-12,13a-dihydro-6-methyl-9H,11H-imidazo[1,5-a]oxazolo[3,2-d][1,4]benzodiazepine

Guidance literature:: With hydrogenchloride; trifluoroborane diethyl ether; potassium carbonate; In dichloromethane; water; 1,2-dichloro-ethane; isopropyl alcohol;

Reference yield:

: 7-chloro-1,3-dihydro-5-(2-fluorophenyl)-2-(1-nitromethylene)-2H-1,4-benzodiazepine 4-oxide

: 59469-38-4
2-Chloro-13a-(2-fluorophenyl)-12,13a-dihydro-6-methyl-9H,11H-imidazo[1,5-a]oxazolo[3,2-d][1,4]benzodiazepine

Guidance literature:: Multi-step reaction with 5 steps

1: aluminum nickel / tetrahydrofuran; methanol

2: PPA; acetic anhydride / methanol; dichloromethane; water

3: hydrogen / dichloromethane; water; acetic acid; Petroleum ether

4: manganese dioxide / toluene

5: hydrogenchloride; trifluoroborane diethyl ether; potassium carbonate / dichloromethane; water; 1,2-dichloro-ethane; isopropyl alcohol

With hydrogenchloride; PPA; manganese dioxide; hydrogen; acetic anhydride; trifluoroborane diethyl ether; potassium carbonate; aluminum nickel; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; 1,2-dichloro-ethane; isopropyl alcohol; toluene; Petroleum ether;

Reference yield:

: 59469-03-3
8-chloro-6-(2-fluorophenyl)-1-hydroxy-methyl-4H-imidazo(1,5-a)(1,4)-benzodiazepine

: 59469-38-4
2-Chloro-13a-(2-fluorophenyl)-12,13a-dihydro-6-methyl-9H,11H-imidazo[1,5-a]oxazolo[3,2-d][1,4]benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; sodium methylate; acetic anhydride / methanol

2: hydrogenchloride; trifluoroborane diethyl ether; potassium carbonate / dichloromethane; water; 1,2-dichloro-ethane; isopropyl alcohol

With pyridine; hydrogenchloride; sodium methylate; acetic anhydride; trifluoroborane diethyl ether; potassium carbonate; In methanol; dichloromethane; water; 1,2-dichloro-ethane; isopropyl alcohol;