2,4-dideoxy-6-O-<(1,1-dimethylethyl)diphenylsilyl>-3,5-O-(1-methylethylidene)-D-erythro-hexitol 1-(2,2-dimethylpropanoate)

Base Information

Chemical Name:2,4-dideoxy-6-O-<(1,1-dimethylethyl)diphenylsilyl>-3,5-O-(1-methylethylidene)-D-erythro-hexitol 1-(2,2-dimethylpropanoate)
CAS No.:114861-34-6
Molecular Formula:C₃₀H₄₄O₅Si
Molecular Weight:512.762
Hs Code.:

Synonyms:2,4-dideoxy-6-O-<(1,1-dimethylethyl)diphenylsilyl>-3,5-O-(1-methylethylidene)-D-erythro-hexitol 1-(2,2-dimethylpropanoate)

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Chemical Property of 2,4-dideoxy-6-O-<(1,1-dimethylethyl)diphenylsilyl>-3,5-O-(1-methylethylidene)-D-erythro-hexitol 1-(2,2-dimethylpropanoate)

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Technology Process of 2,4-dideoxy-6-O-<(1,1-dimethylethyl)diphenylsilyl>-3,5-O-(1-methylethylidene)-D-erythro-hexitol 1-(2,2-dimethylpropanoate)

There total 11 articles about 2,4-dideoxy-6-O-<(1,1-dimethylethyl)diphenylsilyl>-3,5-O-(1-methylethylidene)-D-erythro-hexitol 1-(2,2-dimethylpropanoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 114861-33-5
2,2-Dimethyl-propionic acid 2-((4S,6S)-6-hydroxymethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl ester

: 58479-61-1
tert-butylchlorodiphenylsilane

: 114861-34-6
2,4-dideoxy-6-O-<(1,1-dimethylethyl)diphenylsilyl>-3,5-O-(1-methylethylidene)-D-erythro-hexitol 1-(2,2-dimethylpropanoate)

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 2h;
DOI:10.1021/ja00241a062

Reference yield:

: 81120-67-4
2,4-dideoxy-6-O-(phenylmethyl)-D-erythro-hexitol

: 114861-34-6
2,4-dideoxy-6-O-<(1,1-dimethylethyl)diphenylsilyl>-3,5-O-(1-methylethylidene)-D-erythro-hexitol 1-(2,2-dimethylpropanoate)

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / 4-(dimethylamino)pyridine / pyridine / 5 h / Ambient temperature

2: 93 percent / CSA / 0.5 h / Ambient temperature

3: H₂ / 10percent Pd-C / CH₂Cl₂ / 4 h / 25 °C

4: 73 percent / imidazole / dimethylformamide / 3 h / 25 °C

With 1H-imidazole; hydrogen; dmap; palladium on activated charcoal; camphor-10-sulfonic acid; In pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00222a028

Reference yield:

: 114861-31-3
2,4-dideoxy-6-O-(phenylmethyl)-D-erythro-hexitol 1-(2,2-dimethyl-propanoate)

: 114861-34-6
2,4-dideoxy-6-O-<(1,1-dimethylethyl)diphenylsilyl>-3,5-O-(1-methylethylidene)-D-erythro-hexitol 1-(2,2-dimethylpropanoate)

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / CSA / 0.5 h / Ambient temperature

2: H₂ / 10percent Pd-C / CH₂Cl₂ / 4 h / 25 °C

3: 73 percent / imidazole / dimethylformamide / 3 h / 25 °C

With 1H-imidazole; hydrogen; palladium on activated charcoal; camphor-10-sulfonic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00222a028